Aneuploidy in cancer

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Hematology

Keywords

  • Leukemia, high hyperdiploid, anaplastic thyroid, cancer genomics, aneuploidy, hypodiploidy

Description

We use molecular genetic techniques such as next-generation sequencing and SNP array analysis to identify and characterize acquired genetic aberrations in aneuploid malignancies, with a particular focus on high hyperdiploid and hypodiploid acute lymphoblastic leukemia and anaplastic thyroid cancer. Primary aim To understand how massive chromosomal gain and loss arise and affect cancer cells. Secondary aim To identify novel treatment-stratifying markers and new therapeutic targets in aneuploid malignancies.

Recent research outputs

Studd, J. B., Vijayakrishnan, J., Minjun Yang, Migliorini, G., Kajsa Paulsson & Houlston, R. S. 2017 Mar 3 In : Nature Communications. 8, 14616

Research output: Contribution to journalArticle

Safavi, S. & Kajsa Paulsson 2017 In : Blood. 129, 4, p. 420-423

Research output: Contribution to journalArticle

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