Biogenic Amines

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Pharmacology and Toxicology
  • Cell and Molecular Biology
  • Other Basic Medicine
  • Cancer and Oncology

Research

Cellular proliferation, differentiation and death are all processes playing an active role from embryogenesis to the function of the adult organism. These events are strictly regulated and highly dependent on a multitude of intra- and extracellular factors to proceed normally. The polyamines constitute a group of intracellular growth factors essential for a variety of cellular processes. Depletion of polyamines rapidly induces cell growth arrest, whereas too high levels may cause an induction of cell transformation or cell death. Thus, it is crucial for cells to maintain their polyamine concentrations within rather narrow limits. Polyamine antimetabolites are potential drugs against a large variety of diseases. DFMO, which inhibits the enzyme catalyzing the rate-limiting step in polyamine biosynthesis, is presently the most effective drug against African sleeping sickness. It is capable of curing the most severe cases, in which also the central nervous system is affected.

Recent research outputs

Janina Sprenger, Carey, J., Svensson, B., Wengel, V. & Lo Persson, 2016 Sep 1, In : PLoS ONE. 11, 9, e0163442

Research output: Contribution to journalArticle

Xiaoli Huang, Borgström, B., Kempengren, S., Lo Persson, Cecilia Hegardt, Daniel Strand & Stina Oredsson, 2016, In : BMC Cancer. 16, 1, 145

Research output: Contribution to journalArticle

Burger, P. B., Williams, M., Janina Sprenger, Reeksting, S. B., Botha, M., Mueller, I. B., Joubert, F., Birkholtz, L-M. & Louw, A. I., 2015, In : Malaria Journal. 14, 54

Research output: Contribution to journalArticle

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