Cancer and non coding RNA

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Research

The aims of our research are to contribute to a better understanding of the role of non-coding RNAs in cancer development. The motivation behind our research can be divided in two fields. First, to learn how non-coding RNAs regulate and promote carcinogenesis and secondly, to identify non-coding transcripts that can be used as biomarkers. Our research combines experimental laboratory work with bioinformatics. To characterize the expression of non-coding RNAs in normal tissues and breast tumors we apply massive parallel sequencing techniques. This information is used to find both known non-coding genes associated with disease and to selected genes for in depth studies. This strategy led us to the identification of hundreds new human miRNA genes, the identification of new human miRNAs encoded inside important oncogenes such as the HER2 gene and the characterization of new mechanisms for production of miRNA-like molecules and the control of expression of oncogenic miRNAs.

Recent research outputs

Helena Persson, Rolf Søkilde, Pirona, A. C. & Carlos Rovira 2017 In : BioTechniques. 63, 2, p. 57-64 8 p.

Research output: Contribution to journalArticle

Newie, I., Rolf Søkilde, Helena Persson, Jacomasso, T., Gorbatenko, A., Åke Borg, De Hoon, M., Pedersen, S. F. & Carlos Rovira 2016 Oct 18 In : Scientific Reports. 6, 35664

Research output: Contribution to journalArticle

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