Developmental and Regenerative Neurobiology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Neurosciences
  • Cell and Molecular Biology
  • Medical Biotechnology

Description

My group works with translational stem cell biology. The focus of my research is to understand cell fate specification in the developing brain and in human neural progenitor cells using cell-based models of neuronal differentiation. Our current focus is to learn how to direct and efficiently drive controlled differentiation of human stem cells into subtype-specific neurons. We also develop technologies for direct conversion of human fibroblasts into functional and subtype-specific neurons in vitro, and the conversion of endogenous glia into neurons in vivo. The ultimate aim is to develop these cells and technologies for use in brain repair, with focus on Parkinson’s disease.

Recent research outputs

Thakur, P., Ludivine S. Breger, Lundblad, M., Wan, O. W., Mattsson, B., Luk, K. C., Lee, V. M. Y., Trojanowski, J. Q. & Anders Björklund 2017 Sep 26 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 39, p. E8284-E8293

Research output: Contribution to journalArticle

Kikuchi, T., Morizane, A., Doi, D., Magotani, H., Onoe, H., Hayashi, T., Mizuma, H., Takara, S., Takahashi, R., Inoue, H., Morita, S., Yamamoto, M., Okita, K., Nakagawa, M., Malin Parmar & Takahashi, J. 2017 Aug 30 In : Nature. 548, 7669, p. 592-596 5 p.

Research output: Contribution to journalLetter

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