Developmental Hematopoiesis

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Hematology


  • Hematopoietic stem cells


Hematopoietic stem cells (HSCs) are rare cells located in the bone marrow, which are ultimately responsible for the lifelong generation of all blood cell types. In essence, HSCs ensure these processes by both being able to self-renew, thereby maintaining an adequate pool of HSCs from which differentiation can commence, as well as via tightly regulated differentiation processes, in which the progeny of HSCs become increasingly restricted with regards to differential potential to finally become “locked” to one specific cell lineage. A broader interest of our laboratory is therefore to understand the molecular regulation of HSCs both from the perspectives of self-renewal and differentiation, and how these features become altered upon disease-causing or disease-associated perturbations.

Recent research outputs

Martin Wahlestedt & David Bryder 2017 Dec 1 In : Experimental Hematology. 56, p. 1-6 6 p.

Research output: Contribution to journalArticle

Martin Wahlestedt, Ladopoulos, V., Isabel Hidalgo, Sanchez Castillo, M., Hannah, R., Petter Säwén, Haixia Wan, Monika Dudenhöffer-Pfeifer, Mattias Magnusson, Norddahl, G. L., Göttgens, B. & David Bryder 2017 Nov 21 In : Cell Reports. 21, 8, p. 2251-2263 13 p.

Research output: Contribution to journalArticle

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