Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Immunology in the medical area
- Hematopoiesis, immunology, B cell, lymphocyte, fetal liver, stem cell, barcoding, Lin28
Our team focuses on advancing the conceptual understanding for how the formation of the adaptive immune system changes with developmental timing, and in particular changes in hematopoietic stem cell (HSC) biology and its impact on B cell development and function (Yuan et al, Science, 2012; Kristiansen et al, Immunity, 2016). Using cellular barcoding , VDJ sequencing, and single cell gene expression analysis, we interrogate the ability of stem cell states to impact on downstream fate decisions and immunological diversity. Ongoing projects include: Interrogating the reversibility of adult HSCs to fetal-like plasticity and regenerative potential. Elucidating the basis for the developmental switch in B lineage output early in life. Stratification of the immune system based on developmental timing to visualize the division of labor between fetal and adult hematopoietic stem and progenitor cells.
Recent research outputs
View All (5)
Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during RegenerationKarolina Komorowska, Alexander Doyle, Martin Wahlestedt, Agatheeswaran Subramaniam, Debnath, S., Chen, J., Shamit Soneji, Van Handel, B., Mikkola, H. K. A., Kenichi Miharada, David Bryder, Jonas Larsson & Mattias Magnusson 2017 Dec 19 In : Cell Reports. 21, 12, p. 3514-3523 10 p.
Research output: Contribution to journal › Article