Diabetes and Celiac Unit
Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Endocrinology and Diabetes
- Immunology in the medical area
- Nutrition and Dietetics
- Yype 1 diabetes, Autoimmunity, celiac disease
The field of research is to uncover the genetic and environmental etiology of autoimmune (type 1) diabetes, celiac disease as well as narcolepsy. The genetics of the disease is dissected also in the spontaneously diabetic BB rat. Specific autoantibody markers are used to predict the clinical onset of diabetes or celiac disease. Longitudinal studies of children at increased risk allow studies of the pathogenesis until the clinical onset. Clinical studies are carried out in subjects with one or several autoantibodies as well as at the time of clinical diagnosis to prevent clinical onset or preserve residual beta cells. The goals of our research are to identify the gene-environmental interactions that result in an HLA- associated appearance of autoantibodies against beta-cell autoantigens (insulin, GAD65, IA-2 and ZnT8 and minor autoantigens).
Recent research outputs
First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of ageAlexander Lind, Lynch, K. F., Markus Lundgren, Åke Lernmark, Almgren, P., Ramelius, A., Puustinen, L., Hyöty, H. & Lundstig, A., 2018 Jun 1, In : Journal of Reproductive Immunology. 127, p. 1-6 6 p.
Research output: Contribution to journal › Article
The Better Diabetes Diagnosis (BDD) study – A review of a nationwide prospective cohort study in SwedenPersson, M., C. Becker, H. Elding Larsson, Lernmark, Forsander, G., S. A. Ivarsson, Ludvigsson, J., Samuelsson, U., Marcus, C. & A. Carlsson, 2018 Jun 1, In : Diabetes Research and Clinical Practice. 140, p. 236-244 9 p.
Research output: Contribution to journal › Review article
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