Epigenetics and Diabetes

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Medical Genetics
  • Cell and Molecular Biology

Keywords

  • Epigenetics, DNA, Type 2 diabetes

Description

Type 2 diabetes develops as a conspiracy between the genetic background and the environment. The interaction between genes and environment may involve epigenetic factors, such as DNA methylation and histone modifications, to promote type 2 diabetes. The overall objective of our research is to identify the key epigenetic mechanisms influencing the pathogenesis of T2D. We are currently analysing DNA methylation and histone modifications in a number of human cohorts. Here, we examine if non-genetic and genetic factors as well as type 2 diabetes affect epigenetic variation in human tissues. We are further relating DNA methylation to gene expression, in vivo metabolism and type 2 diabetes. Furthermore, we are dissecting the role of epigenetic enzymes in development of type 2 diabetes.

Recent research outputs

Sonia García-Calzón, Alexander Perfilyev, Männistö, V., de Mello, V., Emma A Nilsson, Pihlajamäki, J. & Charlotte Ling 2017 Sep 21 In : Clinical Epigenetics. 9, 1, p. 1-9 102

Research output: Contribution to journalArticle

Backe, M. B., Andersson, J. L., Karl Bacos, Christensen, D. P., Hansen, J. B., Dorosz, J. J., Gajhede, M., Dahlby, T., Madhusudhan Bysani, Kristensen, L. H., Charlotte Ling, Olsen, L. & Mandrup-Poulsen, T. 2017 Jul 4 In : Molecular and Cellular Endocrinology.

Research output: Contribution to journalArticle

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