Diabetes - Epigenetics

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Medical Genetics
  • Cell and Molecular Biology

Keywords

  • Epigenetics, DNA, Type 2 diabetes

Description

Type 2 diabetes develops as a conspiracy between the genetic background and the environment. The interaction between genes and environment may involve epigenetic factors, such as DNA methylation and histone modifications, to promote type 2 diabetes. The overall objective of our research is to identify the key epigenetic mechanisms influencing the pathogenesis of T2D. We are currently analysing DNA methylation and histone modifications in a number of human cohorts. Here, we examine if non-genetic and genetic factors as well as type 2 diabetes affect epigenetic variation in human tissues. We are further relating DNA methylation to gene expression, in vivo metabolism and type 2 diabetes. Furthermore, we are dissecting the role of epigenetic enzymes in development of type 2 diabetes.

Recent research outputs

Kokosar, M., Benrick, A., Alexander Perfilyev, Emma Nilsson, Källman, T., Ohlsson, C., Charlotte Ling & Stener-Victorin, E., 2018 Dec 1, In : Scientific Reports. 8, 1, 1878

Research output: Contribution to journalArticle

Marti, A., Morell-Azanza, L., Rendo-Urteaga, T., S. García-Calzón, Ojeda-Rodríguez, A., Martín-Calvo, N., Moreno-Aliaga, M. J., Martínez, J. A. & Azcona-San Julián, M. C., 2018 Mar, In : Pediatric Diabetes. 19, 2, p. 217-222 6 p.

Research output: Contribution to journalArticle

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