Experimental Cancer Research, Malmö

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Cell and Molecular Biology

Keywords

  • Cancer metastasis, lipid kinaes, prostate cancer

Description

Existing metastatic disease represents a major clinical challenge. The long-term goal of our study is to gain deeper understanding of cellular mechanisms underlying cancer metastasis. We focus on identification and validation of new predictive biomarkers and drug targets that are specifically for metastatic cancer. We recently focus on studying the role of lipid kinases in particular, phosphatidylinositol 4-phosphate 5-kinase alpha (PIP5K1a) that is responsible for activation PI3K/AKT pathways in cancer cell survival and metastasis. Our study will provide new information to define the complexity of the molecular pathways in cancer metastasis and treatment response, and provide new strategies to improve personalized therapy.

Recent research outputs

Atiomo, W., Shafiee, M. N., Chapman, C., Metzler, V. M., Abouzeid, J., Latif, A., Chadwick, A., Kitson, S., Sivalingam, V. N., Stratford, I. J., Rutland, C. S., Jenny L. Persson, Ødum, N., Fuentes-Utrilla, P., Jeyapalan, J. N., Heery, D. M., Crosbie, E. J. & Mongan, N. P. 2017 Nov 1 In : Clinical Endocrinology. 87, 5, p. 557-565 9 p.

Research output: Contribution to journalArticle

Kunkl, M., Porciello, N., Mastrogiovanni, M., Capuano, C., Lucantoni, F., Moretti, C., Jenny L. Persson, Galandrini, R., Buzzetti, R. & Tuosto, L. 2017 Apr 26 In : Frontiers in Immunology. 8, APR, 502

Research output: Contribution to journalArticle

Fulton, J., Mazumder, B., Whitchurch, J. B., Monteiro, C. J., Collins, H. M., Chan, C. M., Clemente, M. P., Hernandez-Quiles, M., Stewart, E. A., Amoaku, W. M., Moran, P. M., Mongan, N. P., Jenny L. Persson, Ali, S. & Heery, D. M. 2017 Mar 16 In : Cell Death and Disease. 8, 3, p. e2677

Research output: Contribution to journalArticle

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