Fluid resuscitation in critical illness
Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Anesthesiology and Intensive Care
Fluid therapy is a cornerstone in the treatment of critically ill patients and is one of the most common therapies in intensive care units (ICU). However, excessive fluid therapy has side effects such as tissue oedema and compartment syndromes, which may ultimately worsen outcome. The main objective of the project is to optimize fluid therapy in patients suffering from sepsis/SIRS by investigating how fluids should be given with least amount of oedema and other side effects. The research includes preclinical studies of mechanism of importance for regulation of transcapillary fluid exchange and increases in vascular leak in sepsis as well as studies of pharmacodynamics and pharmacokinetics of resuscitation fluids. The project also includes observational clinical studies and clinical trials in which different treatment strategies to restore normovoleima in patients suffering from SIRS are tested.
Recent research outputs
Aspects of fluid therapy in the critically ill. Experimental and clinical studies on fluid therapy in the inflammatory conditions.Svajunas Statkevicius 2018 Lund: Lund University, Faculty of Medicine. 57 p.
Research output: Thesis › Doctoral Thesis (compilation)
Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the ratGustav Folmer Genét, Peter Bentzer, Hansen, M. B., Ostrowski, S. R. & Johansson, P. I. 2018 In : Journal of Trauma and Acute Care Surgery. 84, 1, p. 89-96 8 p.
Research output: Contribution to journal › Article
View All (10)