Genetic chaos in aggressive cancer

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Cell and Molecular Biology

Keywords

  • Sarcoma, Genetics, Osteosarcoma, CRISPR/Cas9

Description

Genetic heterogeneity within a single tumor is the breeding ground for advanced cancer and treatment failure. We study the highly malignant bone tumor osteosarcoma, which has one of the most heterogeneous genomes of all cancers. This is surprising because osteosarcoma primarily affects children and adolescents. These patients have not had the long life behind them thought necessary for the accumulation of massive amounts of somatic mutations. Osteosarcoma therefore serves as the perfect model for the exploration of the origin and consequences of genetic heterogeneity in cancer and holds the key to understanding what is required of a cell to allow rapid manifestation as a high-grade malignancy. Our ultimate aim is to develop new treatment strategies for patients with osteosarcoma and other high-grade malignancies. To this end, we screen primary tumor material for pathogenetic aberrations using next-generation sequencing technology and we manipulate genes of interest in cancer model systems using the CRISPR/Cas

Recent research outputs

Magnusson, L., Hansen, N., Karim H Saba, Nilsson, J., Thoas Fioretos, Rissler, P. & Karolin Hansén Nord 2017 Oct In : Journal of Pathology. 243, 2, p. 160-164

Research output: Contribution to journalArticle

Nils Mandahl, Magnusson, L., Nilsson, J., Viklund, B., Elsa Arbajian, Fredrik Vult Von Steyern, Isaksson, A. & Fredrik Mertens 2017 Jun 24 In : Molecular Cytogenetics. 10, 1, 25

Research output: Contribution to journalArticle

Karolin Hansén Nord, Lilljebjörn, H., Vezzi, F., Nilsson, J., Magnusson, L., Tayebwa, J., de Jong, D., Bovée, J. V. M. G., Hogendoorn, P. C. W. & Szuhai, K. 2014 In : Nature Genetics. 46, 5, p. 474-477

Research output: Contribution to journalArticle

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