Genetic chaos in aggressive cancer

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Cell and Molecular Biology

Keywords

  • Sarcoma, Genetics, Osteosarcoma, CRISPR/Cas9

Description

Genetic heterogeneity within a single tumour is the breeding ground for cancer progression and treatment failure. We study the highly malignant bone tumour osteosarcoma, which has one of the most rearranged genomes of all cancers and a high cell-to-cell variability. This is surprising because osteosarcoma primarily affects children and adolescents. These patients have not had the long life behind them thought necessary for the accumulation of massive amounts of somatic mutations. We believe that this paradox is key in understanding what is required of a cell to allow rapid manifestation as a high-grade malignancy. Our ultimate aim is to develop new treatment strategies for patients with osteosarcoma and other high-grade malignancies. To this end, we screen primary tumour material for pathogenetic aberrations using next-generation sequencing technology and we manipulate genes of interest in cancer model systems using the CRISPR/Cas9 gene editing system.

Recent research outputs

Magnusson, L., Hansen, N., Karim H Saba, Nilsson, J., Thoas Fioretos, Rissler, P. & Karolin Hansén Nord 2017 Oct In : Journal of Pathology. 243, 2, p. 160-164

Research output: Contribution to journalArticle

Nils Mandahl, Magnusson, L., Nilsson, J., Viklund, B., Elsa Arbajian, Fredrik Vult Von Steyern, Isaksson, A. & Fredrik Mertens 2017 Jun 24 In : Molecular Cytogenetics. 10, 1, 25

Research output: Contribution to journalArticle

Karolin Hansén Nord, Lilljebjörn, H., Vezzi, F., Nilsson, J., Magnusson, L., Tayebwa, J., de Jong, D., Bovée, J. V. M. G., Hogendoorn, P. C. W. & Szuhai, K. 2014 In : Nature Genetics. 46, 5, p. 474-477

Research output: Contribution to journalArticle

View All (7)