Hematogenomics

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Immunology in the medical area
  • Immunology
  • Bioinformatics (Computational Biology)

Keywords

  • Multiple myeloma, leukemia, ALL, AML, CRISPR/Cas9, shRNA, Flow cytometry, blood cell formation, population genetics, hematology, genomics, computional biology, bioinformatics

Description

Our research group combines mathematics and genomics to address clinically important problems in hematology and immunology. Current projects focus on blood cell formation and blood disorders, e.g. multiple myeloma and childhood leukemia. The team of computer scientists, clinicians, and molecular biologists work closely together. Computational models are combined with genetic approaches to identify risk genes for blood- and immunological disorders, as well as regulators of the cell functions. Our network of international collaborations include deCODE Genetics and the Broad Institute. Our research has contributed to the understanding of inherited susceptibility to multiple myeloma, the identification of the gene behind the Vel-blood group and a diagnostic tool for the blood group used in clinical practice. Sources of funding include e.g. the Swedish foundation for Strategic Research, the Knut and Alice Wallenberg Foundation, The Swedish Childhood Cancer Foundation and Swedish Research Council.

Recent research outputs

Mina Ali, Ram Ajore, Anna Karin Wihlborg, Abhishek Niroula, Swaminathan, B., Johnsson, E., Stephens, O. W., Morgan, G., Meissner, T., Ingemar Turesson, Goldschmidt, H., Mellqvist, U. H., Urban Gullberg, Markus Hansson, Kari Hemminki, Nahi, H., Waage, A., Weinhold, N. & Björn Nilsson, 2018 Dec 1, In : Nature Communications. 9, 1, 1649

Research output: Contribution to journalArticle

Rick Kapur, Kim, M., Rebetz, J., Hallström, B., Björkman, J. T., Takabe-French, A., Kim, N., Liu, J., Shanmugabhavananthan, S., Milosevic, S., McVey, M. J., Speck, E. R. & John W Semple, 2018 Jul 10, In : Blood Advances. 2, 13, p. 1651-1663

Research output: Contribution to journalArticle

Mina Ali, 2018, Lund: Lund University, Faculty of Medicine. 49 p.

Research output: ThesisDoctoral Thesis (compilation)

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