Hematopoiesis and Gene Therapy

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology

Keywords

  • Hematopoiesis, hematopoietic stem cells, gene therapy

Research

We study the regulation of hematopoietic stem cells in order to understand how signaling pathways, transcriptional mechanisms govern stem cell behavior to determine stem cell fate options. Integrative signaling and transcriptional networks act in concert to determine whether hematopoietic stem cells remain quiescent, proliferate and self-renew, expand through self-renewal, differentiate or undergo apoptosis. We study various regulators to determine how we can 1) expand stem cells 2) understand the pathogenesis of blood malignancies and genetic disorders of the blood system and 3) develop cell and gene therapies. Goals • Develop methods to expand hematopoietic stem cells and early progenitors to improve engraftment following blood and marrow transplantation. • Understand the pathogenesis of Diamond Blackfan anemia and develop mechanism-based therapies for this disorder, including gene therapy. • Develop curative gene therapy for the most common lysosomal storage disorder, Gaucher disease.

Recent research outputs

Rajendran, V. & Mayur Vilas Jain 2018 Methods in Molecular Biology. Humana Press, Vol. 1692, p. 89-95 7 p. (Methods in Molecular Biology; vol. 1692)

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Rörby, E., Billing, M., Maria Dahl, Sarah Warsi, Andradottir, S., Kenichi Miharada, Siva, K., Jönsson, J-I., Blank, U., Göran Karlsson & Stefan Karlsson 2017 Aug 31 In : Scientific Reports. 7, 10134

Research output: Contribution to journalArticle

Shubhranshu Debnath 2017 Lund: Lund University, Faculty of Medicine. 78 p.

Research output: ThesisDoctoral Thesis (compilation)

View All (13)