Hematopoietic Stem Cell Development

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Clinical Laboratory Medicine

Keywords

  • Pluripotent stem cell, induced pluripotent stem cell, hematopoietic stem cell, endothelial to hematopoietic transition, developmental biology, stem cell transplantation

Description

The ultimate goal of our research is to be able to provide an alternative and unlimited source of HLA match hematopoietic stem cells (HSC) for patients in need of HSC transplantation. Our research aims to understand the molecular processes involved in HSC development to be able to mimic normal in vivo development of HSCs in a laboratory culture system. We have already identified numerous of critical factors influencing different stages of the developmental commitment towards the blood lineage. More recently, using single cell transcriptomics we have identified novel precursor cell populations undergoing endothelial-to-hematopoietic transition (EHT). We are first to be able to capture these cells and have functionally assessed their potential. Our research platform allows us characterize the factors required HSC developmental by studying the immediate precursor cells that give rise to HSCs in vitro and comparing them with similar cells from in vivo sources.

Recent research outputs

Rönn, R. E., Carolina Guibentif, Saxena, S. & Niels Bjarne Woods 2017 Jan 1 In : Stem Cells. 35, 1, p. 197-206 10 p.

Research output: Contribution to journalArticle

Carolina Guibentif 2017 Lund: Lund University, Faculty of Medicine. 90 p.

Research output: ThesisDoctoral Thesis (compilation)

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