Hematopoietic Stem Cell Development
Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Cancer and Oncology
- Clinical Laboratory Medicine
- Pluripotent stem cell, induced pluripotent stem cell, hematopoietic stem cell, endothelial to hematopoietic transition, developmental biology, stem cell transplantation
The ultimate goal of our research is to be able to provide an alternative and unlimited source of HLA match hematopoietic stem cells (HSC) for patients in need of HSC transplantation. Our research aims to understand the molecular processes involved in HSC development to be able to mimic normal in vivo development of HSCs in a laboratory culture system. We have already identified numerous of critical factors influencing different stages of the developmental commitment towards the blood lineage. More recently, using single cell transcriptomics we have identified novel precursor cell populations undergoing endothelial-to-hematopoietic transition (EHT). We are first to be able to capture these cells and have functionally assessed their potential. Our research platform allows us characterize the factors required HSC developmental by studying the immediate precursor cells that give rise to HSCs in vitro and comparing them with similar cells from in vivo sources.
Recent research outputs
Term amniotic fluid: An unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applicationsRoksana Moraghebi, Agnete Kirkeby, Chaves, P., Rönn, R. E., Ewa Sitnicka, Malin Parmar, Larsson, M., Andreas Herbst & Niels Bjarne Woods 2017 Aug 25 In : Stem Cell Research and Therapy. 8, 1, 190
Research output: Contribution to journal › Article
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Modelling Human Developmental Hematopoiesis. Towards in vitro Generation of Human Hematopoietic Stem CellsCarolina Guibentif 2017 Lund: Lund University, Faculty of Medicine. 90 p.
Research output: Thesis › Doctoral Thesis (compilation)