HIV-1 and HIV-2 host interactions

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Microbiology in the medical area

Keywords

  • HIV-1, HIV-2, immune response, receptor interactions, chronic immune activation, mycobacterium tuberculosis, co-infection, pathogenesis, variation

Research

There are two types of HIV, HIV-1 and HIV-2, which can lead to AIDS. HIV-1, with global spread, is the more aggressive and infectious virus. The reason for the difference in pathogenesis between HIV-1 and HIV-2 is not yet clear. Our research is focused on understanding the interactions between the immune system and these viruses. We are analyzing cells and antibodies from HIV-1 and/or HIV-2 infected individuals. In parallel, we study the interaction by various in vitro infection models. We are also trying to find out how the immune system is affected by HIV-1-tuberculosis (TB) coinfection. Our collaborators include clinics in Guinea-Bissau, a West African country with high HIV-2 prevalence, clinics in Ethiopia, a country with many HIV-TB coinfected, national and international researchers. Taken together, in addition to basic knowledge on HIV pathogenesis, we anticipate that our studies may contribute to optimized treatment and provide clues to how an effective HIV vaccine should work.

Recent research outputs

Nasi, A., Amu, S., Göthlin, M., Marianne Jansson, Nagy, N., Chiodi, F. & Réthi, B. 2017 Mar 13 In : Frontiers in Immunology. 8, MAR, 244

Research output: Contribution to journalArticle

Bächle, S. M., Malone, D. F. G., Buggert, M., Karlsson, A. C., Per Erik Isberg, Biague, A. J., Hans Norrgren, Patrik Medstrand, Moll, M., Sandberg, J. K. & Marianne Jansson 2016 Jul In : AIDS. 30, 11, p. 1713-1722

Research output: Contribution to journalArticle

Buggert, M., Frederiksen, J., Lund, O., Betts, M. R., Biague, A., Nielsen, M., Tauriainen, J., Hans Norrgren, Patrik Medstrand, Karlsson, A. C. & Marianne Jansson 2016 In : AIDS. 30, 16, p. 2415-2426

Research output: Contribution to journalArticle

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