Immunology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology
  • Immunology in the medical area
  • Cancer and Oncology

Research

Inflammation can be induced both by tissue damage and infection and the purpose of this physiological response is to repair damaged tissue and return it to normalcy. Inflammation is also a central component of both autoimmune disease and cancer. During such conditions, however, the inflammatory response is not properly regulated and the response becomes chronic and a component of disease. The “sterile” inflammation induced upon tissue injury has been shown to be due to be partially caused by the release of components from damaged and dying cells. These so-called DAMP (damage associated molecular patterns) molecules have been shown to be ligands of pro-inflammatory receptors such as TLRs and RAGE.

Recent research outputs

Oruc, Z., Oblet, C., Boumediene, A., Druilhe, A., Pascal, V., Le Rumeur, E., Cuvillier, A., El Hamel, C., Lecardeur, S., Tomas Leanderson, Morelle, W., Demengeot, J., Aldigier, J-C. & Cogné, M. 2016 Sep In : Journal of the American Society of Nephrology : JASN. 27, 9, p. 2748-2761

Research output: Contribution to journalArticle

Dominguez-Valentin, M., Wernhoff, P., Cajal, A. R., Kalfayan, P. G., Piñero, T. A., Gonzalez, M. L., Ferro, A., Sammartino, I., Causada Calo, N. S. & Vaccaro, C. A. 2016 Aug 24 In : Frontiers in Oncology. 6, AUG, 189

Research output: Contribution to journalArticle

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