Immunomodulatory effects of platelets during inflammation and infection
Organisational unit: Research group
Bacteria that breach the bloodstream can cause invasive infectious disease, such as sepsis and septic shock. Platelets are abundant circulating cells with a primary role in blood coagulation. The aim of my research is to elucidate the role of platelets during the pathophysiological response to inflammation and bacterial infection. Projects within the group are focussed on molecular characterisation of platelet activation in response to bacterial pathogens, and the functional consequences for the immune response; leukocytes, endothelial cells and the complement system. The knowledge generated will identify novel targets for diagnosis, prognosis and treatment of these severe manifestations of infectious disease.
Recent research outputs
Antibacterial activity of the contact and complement systems is blocked by SIC, a protein secreted by Streptococcus pyogenes.Inga-Maria Frick, Oonagh Shannon, Per Åkesson, Mörgelin, M., Mattias Collin, Artur Schmidtchen & Lars Björck 2011 In : Journal of Biological Chemistry. 286, p. 1331-1340
Research output: Contribution to journal › Article
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