Immunomodulatory effects of platelets during inflammation and infection

Organisational unit: Research group

Research

Bacteria that breach the bloodstream can cause invasive infectious disease, such as sepsis and septic shock. Platelets are abundant circulating cells with a primary role in blood coagulation. The aim of my research is to elucidate the role of platelets during the pathophysiological response to inflammation and bacterial infection. Projects within the group are focussed on molecular characterisation of platelet activation in response to bacterial pathogens, and the functional consequences for the immune response; leukocytes, endothelial cells and the complement system. The knowledge generated will identify novel targets for diagnosis, prognosis and treatment of these severe manifestations of infectious disease.

Recent research outputs

Hurley, S. M., Lutay, N., Holmqvist, B. & Oonagh Shannon 2016 Sep 1 In : PLoS ONE. 11, 9, e0163531

Research output: Contribution to journalArticle

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