Diabetes - Islet Patophysiology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Medical Genetics
  • Cell and Molecular Biology
  • Physiology

Keywords

  • Type 2 diabetes, nano, islet

Description

We are striving towards the identification of disease-modifying mechanisms that protect endogenous insulin release and diabetes development. Ion channels play overarching roles as sensors of cellular activity and control long-term adaptation of the endocrine pancreatic islet to the environmental demands. Our goals concern signals involved in cellular responses to beta-cell overload: 1)Role of voltage-gated Ca2+ channel subunits and Ca2+ signals for beta-cell gene expression, differentiation status, secretory capacity and diabetes 2)Role of non-voltage-gated ion channels and ligands and mechanical signals for beta-cell gene expression, differentiation status, secretory capacity and diabetes. Novel therapeutic approaches: Superparamagnetic nanoparticles as tools for targeted receptor activation and triggering of mechanosensing

Recent research outputs

Ahlqvist, E. , Storm, P. , Käräjämäki, A. , Martinell, M. , Dorkhan, M. , Carlsson, A. , Vikman, P. , Prasad, R. B. , Aly, D. M. , Almgren, P. , Wessman, Y. , Shaat, N. , Spégel, P. , Mulder, H. , Lindholm, E. , Melander, O. , Hansson, O. , Malmqvist, U. , Lernmark, Å. , Lahti, K. & 4 others Forsén, T., Tuomi, T., Anders H. Rosengren & Leif Groop, 2018 Mar 5, In : The Lancet Diabetes and Endocrinology.

Research output: Contribution to journalArticle

Mahajan, A., Wessel, J., Willems, S. M., Zhao, W., Robertson, N. R., Chu, A. Y., Kravic, J., Emma Ahlqvist, Anders Rosengren, Leif Groop, Tibor V Varga, Paul Franks, Almgren, P., Olle Melander, Marju Orho-Melander & McCarthy, M. I., 2018, In : Nature Genetics. 50, 4, p. 559-571 13 p.

Research output: Contribution to journalArticle

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