Islet patophysiology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Medical Genetics
  • Cell and Molecular Biology
  • Physiology

Keywords

  • Type 2 diabetes, nano, islet

Description

We are striving towards the identification of disease-modifying mechanisms that protect endogenous insulin release and diabetes development. Ion channels play overarching roles as sensors of cellular activity and control long-term adaptation of the endocrine pancreatic islet to the environmental demands. Our goals concern signals involved in cellular responses to beta-cell overload: 1)Role of voltage-gated Ca2+ channel subunits and Ca2+ signals for beta-cell gene expression, differentiation status, secretory capacity and diabetes 2)Role of non-voltage-gated ion channels and ligands and mechanical signals for beta-cell gene expression, differentiation status, secretory capacity and diabetes. Novel therapeutic approaches: Superparamagnetic nanoparticles as tools for targeted receptor activation and triggering of mechanosensing

Recent research outputs

Almgren, P., Andreas Lindqvist, Krus, U., Hakaste, L. H., Ottosson Laakso, E., Olof Asplund, Emily Sonestedt, Rashmi Prasad, Esa Laurila, Marju Orho-Melander, Olle Melander, Tuomi, T., Juul Holst, J., Peter Nilsson, Nils Wierup, Leif Groop & Emma Ahlqvist 2017 Nov 2 In : JCI insight. 2, 21, e93306

Research output: Contribution to journalArticle

Yang De Marinis, Jiangming Sun, Pradeep Bompada, Domènech Omella, J., Cheng Luan, Halu, A., Erik Renström, Sharma, A. & Martin Ridderstråle 2017 Aug 1 In : Obesity. 25, 8, p. 1400-1409 10 p.

Research output: Contribution to journalArticle

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