Lund OsteoArthritis Division - From molecule to clinical implementation

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Orthopedics

Description

Osteoarthritis (OA) is the most frequently occurring joint disease and is characterized by a gradual degradation of joint cartilage as well as pain and loss of function. The disease progression is slow; degradation of cartilage occurs for several years prior to symptoms. Radiological changes occur much later in the process. According to current evidence-based guidelines, the primary treatment is physiotherapy and information, preferably in form of the so-called “Artrosskola”; unfortunately, these guidelines are poorly implemented. We aim to obtain a holistic view of OA. By conducting preclinical as well as clinical studies we intend to identify biological, structural and clinical disease markers in order to discover individuals with OA at an earlier stage than what is possible today, as well as to phenotype patients for increased personalized treatment. We ensure the quality of the “Artrosskola” and develop a digital treatment form using a highly innovative and novel Web-based platform.

Research

Osteoarthritis (OA) is the most frequently occurring joint disease and is characterized by a gradual degradation of joint cartilage as well as pain and loss of function. The disease progression is slow; degradation of cartilage occurs for several years prior to symptoms. Radiological changes occur much later in the process. According to current evidence-based guidelines, the primary treatment is physiotherapy and information, preferably in form of the so-called “Artrosskola”; unfortunately, these guidelines are poorly implemented. We aim to obtain a holistic view of OA. By conducting preclinical as well as clinical studies we intend to identify biological, structural and clinical disease markers in order to discover individuals with OA at an earlier stage than what is possible today, as well as to phenotype patients for increased personalized treatment. We ensure the quality of the “Artrosskola” and develop a digital treatment form using a highly innovative and novel Web-based platform.

Recent research outputs

Shahrzad Hosseininia 2017 Lund: Lund University, Faculty of Medicine. 66 p.

Research output: ThesisDoctoral Thesis (compilation)

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