Lund OsteoArthritis Division - Molecular imaging of joint cartilage using dGEMRIC

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Orthopedics

Research

Hip dysplasia, underdevelopment of the hip joint, can be present at birth but is often not diagnosed until later in life. Slipped Capital Femoral Epiphysis (SCFE) is a disease that affects teenagers and results in various degrees of deformity of the proximal femur. Both diseases are associated with hip osteoarthritis (OA) later in life, although little is known about the causality. In order to establish such relationships and to detect early signs of OA, we employ Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC), which is a non-invasive technique to study joint cartilage quality. We have developed dGEMRIC since the late 1990’s to examine the hip and the knee. Our research aims to establish the long term effects on hip function and cartilage quality, and hence the risk of OA development, in patients with childhood hip dysplasia and SCFE. We also investigate the risk of developing OA in young adult patients with previous knee injury, using dGEMRIC and radiography.