Lymphoid Development and Regulation

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Clinical Laboratory Medicine

Keywords

  • hematopoiesis, immune-deficiencies, NK cells, lymphocytes, immune system

Description

The immune system is composed of myeloid and lymphoid cells that collectively protect the body from bacteria, parasites, fungi, or viruses, and from the growth of tumor cells. Hematopoietic stem cells (HSCs) are ultimately responsible for the production of all cells in the immune system. Natural killer (NK) cells are lymphocytes that play a critical role in preventing cancer and regulating immune responses. The development of mature lymphocytes involves generation of intermediate progenitors that are increasingly restricted in their lineage potential. This differentiation process is driven by a network of transcription factors and extra cellular growth factors and cytokines. The broad interest of our group is to characterize the cellular stages and regulatory pathways governing the development of lymphoid cells in human and in mouse. The gained knowledge could lead to a better understanding of hematopoietic disorders such as immune-deficiencies, myeloproliferative disease and leukemia.

Recent research outputs

Zriwil, A., Charlotta Böiers, Lilian Wittmann, Green, J. C. A., Woll, P. S., Sten Eirik W Jacobsen & Ewa Sitnicka 2016 In : Blood. 128, 2, p. 217-226 10 p.

Research output: Contribution to journalArticle

Renoux, V., Zriwil, A., Peitzsch, C., Michaëlsson, J., Friberg, D., Shamit Soneji & Ewa Sitnicka Quinn 2015 In : Immunity. 43, 2, p. 394-407

Research output: Contribution to journalArticle

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