Medical Molecular Biology
Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Cell and Molecular Biology
- MicroRNA, exosomes, metastases, prostate cancer
Our research aims to deduce the role of microRNAs in prostate cancer initiation and progression. The focus of our research is on the miRNA regulation of the transient processes leading to tumor progression and metastases as the reversibility of this type of regulation present a possible interference option. To capture the dynamic events occurring as the tumour cells transforms in response to the microenvironment we tag the cancer cells and perform functional in vivo screenings, followed by molecular and functional characterization and validations in clinical cohorts, to elucidate what regulate the different steps leading to the metastatic dissemination to different sites. We are also interested in the priming of the metastatic niche by exosomally transferred microRNAs. Together, this will increase the understanding of cancer metastasis and help design novel therapeutic strategies. Enable biomarker-based detection and monitoring cancer progression and subsequent metastatic spread.
Recent research outputs
Clinical-Scale Cell-Surface-Marker Independent Acoustic Microfluidic Enrichment of Tumor Cells from BloodCecilia Magnusson, Per Augustsson, Andreas Lenshof, Yvonne Ceder, Thomas Laurell & Hans Lilja 2017 Nov 21 In : Analytical Chemistry. 89, 22, p. 11954-11961 8 p.
Research output: Contribution to journal › Article
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Yvonne Ceder, Chinnaiyan, A. M., Jenster, G. W., Sorensen, K. D., Tomlins, S., Visakorpi, T. & Calin, G. A. 2016 In : European Urology. 70, 2, p. 312-322
Research output: Contribution to journal › Review article