Medical Molecular Biology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology

Keywords

  • MicroRNA, exosomes, metastases, prostate cancer

Research

Our research aims to deduce the role of microRNAs in prostate cancer initiation and progression. The focus of our research is on the miRNA regulation of the transient processes leading to tumor progression and metastases as the reversibility of this type of regulation present a possible interference option. To capture the dynamic events occurring as the tumour cells transforms in response to the microenvironment we tag the cancer cells and perform functional in vivo screenings, followed by molecular and functional characterization and validations in clinical cohorts, to elucidate what regulate the different steps leading to the metastatic dissemination to different sites. We are also interested in the priming of the metastatic niche by exosomally transferred microRNAs. Together, this will increase the understanding of cancer metastasis and help design novel therapeutic strategies. Enable biomarker-based detection and monitoring cancer progression and subsequent metastatic spread.

Recent research outputs

Fabris, L., Yvonne Ceder, Chinnaiyan, A. M., Jenster, G. W., Sorensen, K. D., Tomlins, S., Visakorpi, T. & Calin, G. A. 2016 In : European Urology. 70, 2, p. 312-322

Research output: Contribution to journalReview article

Haflidadottir, B. & Yvonne Ceder 2015 In : European Urology. 67, 1, p. 42-43

Research output: Contribution to journalDebate/Note/Editorial

Larne, O., Hagman, Z., Hans Lilja, Anders Bjartell, Edsjö, A. & Yvonne Ceder 2015 In : Carcinogenesis. 36, 8, p. 858-866

Research output: Contribution to journalArticle

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