Molecular oncology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology
  • Cancer and Oncology

Keywords

  • neuroblastoma, childhood tumor, hypoxia, cancer stem cells

Description

Neuroblastoma is a childhood tumor that sometimes appears as very aggressive and even incurable. Our aim is to unravel new ways to target aggressive neuroblastoma with the intention of increasing survival for high-risk patients and hopefully reducing toxic side effects of conventional treatment. In our research we utilize patient-derived xenografts (PDXs) and cultured neuroblastoma spheroids derived from PDXs. We have shown that these models are reliable as they recapitulate important traits of aggressive neuroblastoma, such as metastatic growth pattern. We study phenotypically different subpopulations of neuroblastoma in order to elucidate whether a specific subgroup causes tumor relapse and if such populations can be targeted with a specific treatment. Our research also concerns the pseudohypoxic phenotype in neuroblastoma.

Recent research outputs

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