Molecular therapeutics in breast cancer

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology


Our ultimate research goal is to find improved ways to treat patients with metastatic breast cancer. Although significant progress in treatment strategies has been made during the last decades, many breast cancer patients still relapse and to date metastatic breast cancer remains an incurable disease. We aim to identify the signalling pathways active in recurrent disease in order to study response to targeted therapeutics against such pathways and to better understand resistance mechanisms. Ongoing projects: 1. Identification of mechanisms that cause acquired resistance to endocrine therapy in metastatic breast cancer. 2. Study of the involvement of cancer stem cells in development of resistance to endocrine treatment. 3. Study of the downstream effectors in MYC driven triple negative breast tumours to find druggable targets in this elusive subtype of breast cancer. 4. Investigate tumour evolution and development of “liquid biopsies” as a surrogate for tumour biopsies.

Recent research outputs

Perez-Gracia, J. L. , Sanmamed, M. F. , Bosch Campos, A. , Patiño-Garcia, A. , Schalper, K. A. , Segura, V. , Bellmunt, J. , Tabernero, J. , Sweeney, C. J. , Choueiri, T. K. , Martín, M. , Fusco, J. P. , Rodriguez-Ruiz, M. E. , Calvo, A. , Prior, C. , Paz-Ares, L. , Pio, R. , Gonzalez-Billalabeitia, E. , Gonzalez Hernandez, A. , Páez, D. & 15 others Piulats, J. M., Gurpide, A., Andueza, M., Velasco, G., Pazo, R., Grande, E., Nicolas, P., Abad-Santos, F., Garcia-Donas, J., Castellano, D., Pajares, M. J., Suarez, C., Colomer, R., Montuenga, L. M. & Melero, I., 2017 Feb 1, In : Cancer Treatment Reviews. 53, p. 79-97

Research output: Contribution to journalReview article

Bosch Campos, A. , Li, Z. , Bergamaschi, A. , Ellis, H. , Toska, E. , Prat, A. , Tao, J. J. , Spratt, D. E. , Viola-Villegas, N. T. , Castel, P. , Minuesa, G. , Morse, N. , Rodón, J. , Ibrahim, Y. , Cortes, J. , Perez-Garcia, J. , Galvan, P. , Grueso, J. , Guzman, M. , Katzenellenbogen, J. A. & 8 others Kharas, M., Lewis, J. S., Dickler, M., Serra, V., Rosen, N., Chandarlapaty, S., Scaltriti, M. & Baselga, J., 2015 Apr 15, In : Science Translational Medicine. 7, 283, p. 1-11 283ra51

Research output: Contribution to journalArticle

Gabriella Honeth, Schiavinotto, T., Vaggi, F., Marlow, R., Kanno, T., Shinomiya, I., Lombardi, S., Buchupalli, B., Graham, R., Gazinska, P., Ramalingam, V., Burchell, J., Purushotham, A. D., Pinder, S. E., Csikasz-Nagy, A. & Dontu, G., 2015 Apr 14, In : Stem Cell Reports. 4, 4, p. 699-711 13 p.

Research output: Contribution to journalArticle

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