Molecular virology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Microbiology in the medical area
  • Cell and Molecular Biology

Keywords

  • Virology, virus, HPV, influenza virus, HIV, RNA, RNA processing, splicing, gene regulation, papillomavirus, polyadenylation

Description

Viruses are small parasites that infect living cells to multiply their genomes and to produce new virus particles. Understanding of viral replication and gene expression is of paramount importance to determine how viruses cause disease and for development of antiviral drugs. Research efforts in the group: Human papillomavirus type 16 (HPV16) is a sexually transmitted virus. The infection is normally asymptomatic and is cleared within a year or two. In rare cases, the HPV16 infection persists and may cause lesions that progress to cancer, primarily cervical cancer in women. To understand how HPV16 can persist in its host, we are investigating how HPV16 regulates the expression of its genes, in particular expression of the highly immunogenic late L1 and L2 proteins. Influenza virus avoids immunity in the human population dues to its high variability. We are investigating if changes in the viral RNA genome affect the function of the viral mRNAs.

Recent research outputs

Kajitani, N., Glahder, J., Wu, C., Yu, H., Kersti Nilsson & Stefan Schwartz 2017 Sep 19 In : Nucleic Acids Research. 45, 16, p. 9654-9678 25 p.

Research output: Contribution to journalArticle

Troy Chengjun Wu, Kajitani, N. & Stefan Schwartz 2017 Feb 9 In : International Journal of Molecular Sciences. 18, 2, 366

Research output: Contribution to journalReview article

Johansson, C., Jamal Fattah, T., Yu, H., Nygren, J., Mossberg, A. & Stefan Schwartz 2015 In : Virology. 482, p. 244-259

Research output: Contribution to journalArticle

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