Pathways of cancer cell evolution

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Genetics
  • Cancer and Oncology
  • Pediatrics
  • Biomedical Laboratory Science/Technology

Keywords

  • Pathology, Paediatrics, Childhood cancer

Description

We make genetic and functional maps of cancer cell evolution in patients by analyzing multiple tumour samples from the same patient. In particular, we aim to: 1. Make phylogenetic maps of cancer cell variation over anatomic space and treatment time in order to understand the conditions leading to treatment resistance; 2. Assess the functional effect on the RNA and protein levels of genetic variation in tumours; 3. Analyze to what extent clinical biomarkers exhibit variability within a tumour lineage – a potentially important source of error in clinical decision making; 4. Evaluate the potential of using parameters of genetic variation as biomarkers for response to treatment. To reach these aims we use a combination of traditional histopathology and next-generation sequencing technologies. We focus on three of the most common solid tumours in children: neuroblastoma, Wilms tumour and rhabdomyosarcoma.

Recent research outputs

Hero, B., Clement, N., Ingrid Øra, Pierron, G., Lapouble, E., Theissen, J., Pasqualini, C., Valteau-Couanet, D., Plantaz, D., Michon, J., Delattre, O., Tardieu, M. & Schleiermacher, G. 2018 In : Journal of Pediatric Hematology/Oncology. 40, 2, p. 93-98

Research output: Contribution to journalArticle

Anders Valind 2017 Dec 15 Lund: Lund University, Faculty of Medicine. 58 p.

Research output: ThesisDoctoral Thesis (compilation)

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