Pediatric Nephrology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Pediatrics
  • Gastroenterology and Hepatology

Research

Diana Karpman's project focuses on the pathogenesis of renal diseases and the infectious, inflammatory and prothrombotic mechanisms leading to acute and chronic renal failure. Novel mechanisms of disease propagation via blood-borne and cell-derived microvesicles as well as complement and kinin system activation are investigated. The diseases investigated are enterohemorrhagic Escherichia coli (EHEC) infection, hemolytic uremic syndrome, complement-mediated renal disease and vasculitis. Mechanisms by which tissue damage is induced are investigated to define the bacterial and host components causing disease. Defining mechanisms of complement and kinin system activation based on genetic and functional assays may explain why patients are prone to thrombosis and inflammation promoting progression of kidney disease. Ultimately, we aim to develop specific treatments to prevent the spread of bacterial virulence factors and neutralize detrimental activation of the complement and kinin systems.

Recent research outputs

Diana Karpman & Peter Höglund 2017 Jan In : Pediatric Nephrology. 32, 1, p. 1-6

Research output: Contribution to journalDebate/Note/Editorial

Maria Mossberg 2017 Lund: Lund University, Faculty of Medicine. 82 p.

Research output: ThesisDoctoral Thesis (compilation)

Diana Karpman, Fehrman-Ekholm, I., Bárány, P., Zivile Békássy, Brandström, P., Bruchfeld, A., Celsi, G., Milan Chromek, Naomi Clyne, Fellström, B., Hansson, S., Haraldsson, B., Nevéus, T., Rippe, B., Sartz, L., Mårten Segelmark, Stegmayr, B., Stenvinkel, P., Tufveson, G. & Kerstin Westman 2015 In : Lakartidningen. 112

Research output: Contribution to journalDebate/Note/Editorial

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