Protein Chemistry, Malmö

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Immunology in the medical area
  • Microbiology in the medical area
  • Rheumatology and Autoimmunity

Keywords

  • Complement system

Description

Our research is focused on the regulation of the complement system in health and disease. Complement is crucial part of innate immunity and thus protects host from infections and contributes to removal of dying cells. We study involvement of complement in pathology of rheumatic and inflammatory diseases as well as several types of cancer. Further, we investigate strategies developed by bacterial pathogens in order to avoid killing by complement, which results in infections. Our main focus is on various complement inhibitors such as C4BP and factor I but also newly discovered regulators such as SUSD4, CSMD1 and COMP. Recently we expanded our research into intracellular functions of complement proteins in particular in pancreatic beta cells.

Recent research outputs

Yan Borné, Iram Faqir Muhammad, Lorés-Motta, L., Bo Hedblad, Peter M. Nilsson, Olle Melander, de Jong, E. K., Anna M. Blom, den Hollander, A. I. & Gunnar Engström 2017 Dec 1 In : The Journal of clinical endocrinology and metabolism. 102, 12, p. 4477-4485 9 p.

Research output: Contribution to journalArticle

Anna M. Blom, Michal Magda, Kohl, L., Shaughnessy, J., Lambris, J. D., Ram, S. & David Ermert 2017 Dec 1 In : Journal of Immunology. 199, 11, p. 3828-3839 12 p.

Research output: Contribution to journalArticle

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