Quantitative infection biology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Infectious Medicine


Bacterial infections represent a major global health issue and more detailed knowledge about host-bacteria interactions are needed to counteract the rising bacterial resistance to antibiotics. The Nordenfelt Lab uses unique biosensor technology in conjunction with advanced live imaging and image analysis techniques to study initial host-pathogen interactions. The molecular surface composition of bacteria and human cells are analyzed and related to each other at a single-bacterium level, allowing for a direct link between receptor activity and the number of molecules at each interaction site. With this information it is possible start unraveling the molecular basis for the first steps of bacterial pathogenesis. The overall goal of the research is through better understanding at the molecular level open up new targets for antibacterial treatments and diagnostics.

Recent research outputs

Pontus Nordenfelt, Cooper, J. M. & Hochstetter, A., 2018 Jun 25, In : Optics Express. 26, 13, p. 17279-17288 10 p.

Research output: Contribution to journalArticle

Pontus Nordenfelt (ed.) & Mattias Collin (ed.), 2017, 1 ed. Humana Press. 357 p. (Methods in Molecular Biology; vol. 1535)

Research output: Book/ReportAnthology (editor)

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