Rausing laboratory of Lund - Tumor section
Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Cancer and Oncology
- Glioblastoma, experimental models, immunotherapy, radiotherapy
Malignant gliomas are the most common primary brain tumors. One major problem is that the tumor cells evade the patients’ own immune response. We focus our research upon this. We have developed a glioma cell line with green fluorescent tumor cells that are inoculated into immunocompetent rats, and hereby we follow tumor cell infiltration. Complement activation in malignant gliomas. Our co-operation partner Kurt Osther has seen that human glioma cells express factors suppressing the complement activation. We investigate this in other human cell lines and rat glioma cell lines, and run animal experiments where the complement inactivation is targeted with antibodies. Combated radio-immunotherapy. It is known that low-dose radiotherapy can promote the immune response. We have studied the effect of combined radio-immunotherapy, and seen that this can lead to increased survival, for example when combined with IDO inhibition. IDO is an immune suppressive protein expressed in glioma cells.
Recent research outputs
Exploration of Electro-Enhanced-Chemotherapy II.: Uptake of radioactive tracer in rat Muscle tissue at 6 and 24 hours after applied electric pulses of 1000 V/cm field-strength, 100 micro-s pulse-length, and various number of pulses.Bertil R Persson 2017 Oct 12 In : Acta Scientiarum Lundensia. 2017, 003, p. 1-21 21 p.
Research output: Contribution to journal › Article
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