Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Infectious Medicine
Redox reactions and oxidative stress has been implicated as an important factor in the progression of many disease conditions, such as hemorrhage, inflammation, infection, ischemia-reperfusion and tumor targeted radiation. During these conditions increased levels of free radicals are generated, causing an imbalance in the redox-system that leads to oxidation of cells and molecules and subsequent tissue and organ damage.
Hemolysis of erythrocytes releases high levels of cell-free hemoglobin and its metabolites, which are potentially dangerous molecules contributing to tissue and cell damage via redox-reactions. Our research aim to characterize these pathophysiological reactions mechanisms and their importance in diseases, focusing on the immature brain and kidneys. Furthermore, we study defense mechanisms that protect against these reactions with a special emphasis on the heme- and radical-scavenging protein A1M. Of particular interest is evaluating A1M as therapy for these conditions.
Recent research outputs
Cerebellar Exposure to Cell-Free Hemoglobin Following Preterm Intraventricular Hemorrhage: Causal in Cerebellar Damage?Alex Adusei Agyemang, Kristbjörg Sveinsdóttir, Suvi Vallius, SVEINSDOTTIR, S. N. J. O. L. A. U. G., Matteo Bruschettini, Romantsik, O., Hellström, A., Smith, L. E. H., Ohlsson, L., Holmqvist, B., Magnus Gram & David Ley 2017 Jun 10 In : Translational Stroke Research. p. 1-13 13 p.
Research output: Contribution to journal › Article
View All (12)
Pathophysiology of extracellular haemoglobin: use of animal models to translate molecular mechanisms into clinical significanceEmanuel Smeds, Romantsik, O., Åsa Jungner, Lena Erlandsson & Magnus Gram 2017 In : ISBT Science Series. 12, 1, p. 134-141 8 p.
Research output: Contribution to journal › Review article