Retinal degeneration: Molecular Pathology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Ophthalmology

Research

The rod and cone photoreceptors in the retina of the eye are crucial for our vision, but also vulnerable to diseases, which can make them degenerate and die. Such diseases include Retinitis pigmentosa (RP), a heritable disease with a prevalence of about 1 in 3.000 – 4000 people. RP comes from gene mutations but it is not clear how these cause the degeneration and there are no therapies available. We are therefore investigating the mechanisms behind RP: The more that is known about these, the easier it will be to come up with good ideas for treatment strategies. In our research we use RP-models, for instance rd1. We have observed that an enzyme system, the cGMP system, plays a critical role in the degeneration and that cGMP levels are increased in the RP photoreceptors. The cGMP system is hence an interesting target for treatment, and a therapy development based on this has started. An important question that we now work with is: What is the high cGMP causing in the photoreceptors?

Recent research outputs

Azadi, S., Paquet-Durand, F., Patrik Medstrand, van Veen, T. & Per Ekström 2006 In : Molecular and Cellular Neuroscience. 31, 4, p. 759-773

Research output: Contribution to journalArticle

Ahuja, P., Caffé, R., Sat pal Ahuja, Per Ekström & van Veen, T. 2005 In : Neuroscience. 131, 4, p. 935-943

Research output: Contribution to journalArticle

Per A R Ekström, Kerekes, N. & Hökfelt, T. 2000 Mar 10 In : Neuroscience Letters. 281, 2-3, p. 107-110 4 p.

Research output: Contribution to journalArticle

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