Stem Cell Metabolism

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology

Keywords

  • Hematopoiesis, unfolded protein stress, red blood cell, bile acid, erythropoiesis

Research

Hematopoiesis is a well-balanced system that requires both consistency and flexibility. Although the potential of hematopoietic stem cells (HSCs) has intensively been studied, contributions of these cells in different occasions and their regulations are still unclear. Our research group therefore aims to understand molecular mechanisms and cellular dynamics of HSCs, particularly under proliferative and stressed conditions. Concretely, we study (1) how different kinds of stress impact on cellular metabolism and stem cell heterogeneity, (2) how cells manage such stress conditions, and (3) what types of factors can play the role in the regulations. These are crucial for investigating molecular/cellular mechanisms involved in normal and malignant hematopoiesis, and also equally imperative for developing new technologies in order to expand/produce functional blood cells.

Recent research outputs

Rörby, E., Billing, M., Maria Dahl, Sarah Warsi, Andradottir, S., Kenichi Miharada, Siva, K., Jönsson, J-I., Blank, U., Göran Karlsson & Stefan Karlsson 2017 Aug 31 In : Scientific Reports. 7, 10134

Research output: Contribution to journalArticle

Prost, G., Sebastian Braun, Hertwig, F., Winkler, M., Jagemann, L., Sara Nolbrant, Leefa, I. V., Offen, N., Kenichi Miharada, Lang, S., Isabella Artner & Nuber, U. A. 2016 Sep 6 In : Oncotarget. 7, 36, p. 58203-58217 15 p.

Research output: Contribution to journalArticle

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