Stem Cells and Leukemia

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Hematopoiesis, Leukemia, Stem Cells, Single-Cell Analysis

Research

The production of blood cells, hematopoiesis, is maintained by a small number of hematopoietic stem cells (HSCs) that have the capacity to differentiate into all hematopoietic lineages, and at the same time self-renew to maintain the HSC pool. Similarly to normal hematopoiesis, leukemias are organized in cellular hierarchies where leukemic stem cells (LSCs) drive tumor growth. LSCs have stem cell characteristics such as self-renewal capacity, quiescence and drug resistance, causing metastasis and relapse. LSCs are therefore a critical priority as targets for therapy. Our objective is to use single-cell methods to dissect the heterogeneity of stem cell populations and discriminate between HSCs and LSCs. This will allow for defining the transcriptional programs that govern HSC fate and explain the molecular basis for leukemogenesis as well as therapy resistance. Ultimately we will use this information to therapeutically target LSCs and thereby improve the treatment of leukemia.

Recent research outputs

Rörby, E., Billing, M., Maria Dahl, Sarah Warsi, Andradottir, S., Kenichi Miharada, Siva, K., Jönsson, J-I., Blank, U., Göran Karlsson & Stefan Karlsson 2017 Aug 31 In : Scientific Reports. 7, 10134

Research output: Contribution to journalArticle

Carolina Guibentif, Rönn, R. E., Charlotta Böiers, Lang, S., Saxena, S., Shamit Soneji, Tariq Enver, Göran Karlsson & Niels-Bjarne Woods 2017 Apr 4 In : Cell Reports. 19, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

Rebecca Warfvinge, Linda Geironson Ulfsson, Mikael N E Sommarin, Lang, S., Christine Karlsson, Roschupkina, T., Stenke, L., Stentoft, J., Olsson-Strömberg, U., Hjorth-Hansen, H., Mustjoki, S., Shamit Soneji, Richter, J. & Göran Karlsson 2017 Apr In : Blood. 129, 17, p. 2384-2394

Research output: Contribution to journalArticle

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