Systemic Radiation Therapy Group

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • Nuclear Medicine, Medical Imaging, Molecular Imaging, Radioimmunotherapy, Radiation Therapy, Dosimetry, Prostate Cancer, hk2

Research

The main research area of the group is systemic treatment of metastasized cancer using therapeutic radionuclides. To optimize dose delivery to tumor cells, radionuclides are conjugated to tracer molecules, e.g. antibodies or antibody fragments, targeting cancer-specific epitopes. Preclinical evaluation of treatment combinations and strategies aim to improve treatment efficacy. Multimodality imaging such as SPECT/PET/CT, and Cerenkov and Bioluminescence Imaging are also employed to evaluate tracer biokinetics, biological effects and properties such as tumor uptake and penetration. Improving micro- and macro-scale dosimetry models and apply them using input from e.g. imaging modalities is another key aim. The group combines basic research with translational efforts, aiming to implement novel radionuclide therapies in the clinic. The current focus is on prostate cancer radioimmunotherapy targeting human kallikrein-related peptidase 2 (hK2), following promising preclinical results.

Recent research outputs

McDevitt, M. R., Thorek, D. L. J., Hashimoto, T., Gondo, T., Veach, D. R., Sharma, S. K., Kalidindi, T. M., Abou, D. S., Watson, P. A., Beattie, B. J., Oskar Vilhemsson Timmermand, Sven Erik Strand, Lewis, J. S., Scardino, P. T., Scher, H. I., Hans Lilja, Larson, S. M. & David Ulmert, 2018 Dec 1, In : Nature Communications. 9, 1, 1629

Research output: Contribution to journalArticle

Renata Madru, Budassi, M., Benveniste, H., Lee, H., Smith, S. D., Schlyer, D. J., Vaska, P., Linda Knutsson & Sven-Erik Strand, 2018 Aug, In : Cancer Biotherapy & Radiopharmaceuticals. 33, 6, p. 213-220 8 p.

Research output: Contribution to journalArticle

Emma Mellhammar, Dahlbom, M., Susan Evans-Axelsson, Axelsson, J., Thuy Tran & Sven-Erik Strand, 2017 Oct 16, 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016. Institute of Electrical and Electronics Engineers Inc., Vol. 2017-January, 8069462

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

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