Translational Neuroendocrinology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Neurology

Keywords

  • Huntington disease, depression, hypothalamus, psychiatry, neurodegenerative

Research

The research group studies the underlying pathogenic mechanisms of the neurodegenerative and neuropsychiatric Huntington disease (HD) with the ultimate aim to develop novel effective therapies. HD is a devastating disorder always caused by an expanded CAG triplet repeat mutation in the huntingtin gene. Importantly, individuals with the mutant HD gene suffer from psychiatric symptoms and metabolic dysfunction many years before onset of typical motor symptoms. Our hypothesis is that the non-motor features are due to hypothalamic pathology. We have previously shown that hypothalamic changes occur early in clinical HD and we have established a causal relationship between hypothalamic huntingtin and the development of metabolic and psychiatric disturbances in mice. Ongoing work will identify key molecular pathways and the critical neuronal circuitries affected early in the HD hypothalamus in order to develop disease modifying treatments.

Recent research outputs

Siebzehnrübl, F. A. , Raber, K. A. , Urbach, Y. K. , Schulze-Krebs, A. , Canneva, F. , Moceri, S. , Habermeyer, J. , Achoui, D. , Gupta, B. , Steindler, D. A. , Stephan, M. , Nguyen, H. P. , Bonin, M. , Riess, O. , Bauer, A. , Aigner, L. , Couillard-Despres, S. , Paucar, M. A. , Svenningsson, P. , Osmand, A. & 11 others Andreew, A., Zabel, C., Weiss, A., Kuhn, R., Moussaoui, S., Blockx, I., Van der Linden, A., Rachel Y. Cheong, Laurent Roybon, Åsa Petersén & Von Hörsten, S., 2018 Sep 11, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8765-E8774

Research output: Contribution to journalArticle

Ast, A. , Buntru, A. , Schindler, F. , Hasenkopf, R. , Schulz, A. , Brusendorf, L. , Klockmeier, K. , Grelle, G. , McMahon, B. , Niederlechner, H. , Jansen, I. , Diez, L. , Edel, J. , Boeddrich, A. , Franklin, S. A. , Baldo, B. , Schnoegl, S. , Kunz, S. , Purfürst, B. , Gaertner, A. & 6 others Kampinga, H. H., Morton, A. J., Åsa Petersén, Kirstein, J., Bates, G. P. & Wanker, E. E., 2018 Sep 6, In : Molecular Cell. 71, 5, p. 675-688.e6

Research output: Contribution to journalArticle

Karolina Pircs, Petri, R., Madsen, S., Per Ludvik Brattås, Vuono, R., Daniella R. Ottosson, St-Amour, I., Hersbach, B. A., Matusiak-Brückner, M., Lundh, S. H., Åsa Petersén, Déglon, N., Hébert, S. S., Malin Parmar, Roger A. Barker & Johan Jakobsson, 2018 Aug, In : Cell Reports. 24, 6, p. 1397-1406 10 p.

Research output: Contribution to journalArticle

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