Darcy Wagner

Associate Senior Lecturer, Bachelor of Science in Mechanical Engineering (BSME), Doctor of Philosophy (PhD) in Biomedical Engineering

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology
  • Biomaterials Science
  • Manufacturing, Surface and Joining Technology

Keywords

  • Lung Regeneration, Tissue Engineering, Stem Cells, Biomaterials, Mechanotransduction, Hippo, Wnt, Bioengineering, Ex vivo, Bioreactor

Research

Over three million people die each year and over 60 million people suffer worldwide from chronic lung diseases (CLDs). At present, there is no cure for CLDs, including chronic obstructive pulmonary disease (COPD), pulmonary hypertension, and pulmonary fibrosis. Lung transplantation is the only option at end-stage disease and is further complicated by shortage in organs available for transplantation and low efficacy. Five-year survival rate has remained at 50% for the last decade. New options are desperately needed for these patients.

My lab focuses on understanding the role of the extracellular environment for endogenous and exogenous lung tissue regeneration in healthy and diseased lung. In particular, our work focuses on the design and use of biologic and synthetic scaffolds to bioengineer new lung tissue for transplantation. We further aim to build new models of human lung tissue to reduce animal usage, better understand how regeneration processes are deranged in CLDs, and for use as drug discovery and therapeutic screening platforms.

Highlighted research outputs

Jiang, D., Correa-Gallegos, D., Christ, S., Stefanska, A., Liu, J., Ramesh, P., Rajendran, V., Martina M. De Santis, Darcy E. Wagner & Rinkevich, Y., 2018 Apr 1, In : Nature Cell Biology. 20, 4, p. 422-431 10 p.

Research output: Contribution to journalArticle

Lehmann, M., Korfei, M., Mutze, K., Klee, S., Skronska-Wasek, W., Hani N. Alsafadi, Ota, C., Costa, A. R., Schiller, H. B., Lindner, M., Darcy E Wagner, Günther, A. & Königshoff, M., 2017 Aug, In : European Respiratory Journal. 50, p. 1-15 1602367

Research output: Contribution to journalArticle

Skronska-Wasek, W., Mutze, K., Baarsma, H. A., Bracke, K. R., Hani N. Alsafadi, Lehmann, M., Costa, A. R., Stornaiuolo, M., Novellino, E., Brusselle, G., Darcy E. Wagner, Yildirim, A. O. & Königshoff, M., 2017 Jul 15, In : American Journal of Respiratory and Critical Care Medicine. 196, 2, p. 172-185 14 p.

Research output: Contribution to journalArticle

Hani N. Alsafadi, Staab-Weijnitz, C. A., Lehmann, M., Lindner, M., Peschel, B., Königshoff, M. & Darcy E. Wagner, 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 6, p. L896-L902

Research output: Contribution to journalArticle

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