David Gisselsson Nord

Professor, Specialist Physician, Senior Consultant PathologistFormer name: David Gisselsson

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Pathology, Paediatrics, Cancer, Childhood cancer

Research

David Gisselsson Nord has published >100 research papers and received the Fernström Prize to young investigators in 2014.
 
Genetic topography of childhood cancer
We make genetic and functional maps of cancer cell evolution in patients by analyzingmultiple tumour samples from the same patient. In particular we aim to:
 
1. Make phylogenetic maps of cancer cell variation over anatomic space andtreatment time in order to understand the conditions leading to treatment resistance;
 
2. Assess the functional effect on the RNA and protein levels of genetic variation in tumours;
 
3. Analyze to what extent clinical biomarkers exhibit variability within a tumourlineage – a potentially important source of error in clinical decision making;
 
4. Evaluate the potential of using parameters of genetic variation as biomarkers for response to treatment.
 
To reach these aims we use a combination of traditional histopathology and next-generation sequencing technologies. We focus on three of the most common solidtumours in children: neuroblastoma, Wilms tumour and rhabdomyosarcoma.

Professional work

David Gisselsson Nord is professor of molecular pathology and runs a research group aiming to resolve mechanisms of cancer cell evolution (diversity) including its implications for biomarker reliability and chemotherapy resistance. He is also a clinically active perinatal and peadiatric pathologist with a background in clinical genetics.

 

Highlighted research outputs

Holmquist Mengelbier, L. , Karlsson, J. , Lindgren, D. , Valind, A. , Bexell, D. , Braekeveldt, N. , Jonson, T. , Isaksson, A. , Fioretos, T. , Øra, I. , Gisselsson Nord, D. & 12 others Lilljebjörn, H., Jansson, C., Ameur, A., Kultima, H. G., Asmundsson, J., Versteeg, R., Rissler, M., Sandstedt, B., Börjesson, A., Backman, T., Pal, N. & Mayrhofer, M. 2015 In : Nature Communications. 6, 6125

Research output: Contribution to journalArticle

David Gisselsson Nord, Jin, Y., David Lindgren, Persson, J., Gisselsson, L., Hanks, S., Sehic, D., Linda Holmquist Mengelbier, Ingrid Øra, Rahman, N., Fredrik Mertens, Felix Mitelman & Nils Mandahl 2010 In : Proceedings of the National Academy of Sciences. 107, 47, p. 20489-20493

Research output: Contribution to journalArticle

View all (129)