Eva Degerman

Professor
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  1. 2017
  2. Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes

    Johanna Säll, Pettersson, A. M. L., Björk, C., Henriksson, E., Sebastian Wasserstrom, Linder, W., Zhou, Y., Ola Hansson, Andersson, D. P., Mikael Ekelund, Eva Degerman, Karin G Stenkula, Laurencikiene, J. & Olga Göransson 2017 Feb In : Diabetologia. 60, 2, p. 314–323

    Research output: Contribution to journalArticle

  3. White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function

    Chung, Y. W., Ahmad, F., Tang, Y., Hockman, S. C., Kee, H. J., Karin Berger, Guirguis, E., Choi, Y. H., Schimel, D. M., Aponte, A. M., Park, S., Eva Degerman & Manganiello, V. C. 2017 Jan 13 In : Scientific Reports. 7, 40445

    Research output: Contribution to journalArticle

  4. 2016
  5. 2015
  6. Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets

    Ahmad, F., Murata, T., Shimizu, K., Eva Degerman, Maurice, D. & Manganiello, V. 2015 In : Oral Diseases. 21, 1, p. E25-E50

    Research output: Contribution to journalReview article

  7. Regulation of SERCA2 activity by PDE3A in human myocardium: Phosphorylation-dependent interaction of PDE3A1 with SERCA2.

    Ahmad, F., Shen, W., Vandeput, F., Szabo-Fresnais, N., Krall, J., Eva Degerman, Goetz, F., Klussmann, E., Movsesian, M. & Manganiello, V. 2015 In : Journal of Biological Chemistry. 290, 11, p. 6763-6776

    Research output: Contribution to journalArticle

  8. SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes

    Henriksson, E., Johanna Sernevi Säll, Gormand, A., Sebastian Wasserstrom, Morrice, N. A., Fritzen, A. M., Foretz, M., Campbell, D. G., Sakamoto, K., Mikael Ekelund, Eva Degerman, Karin Stenkula & Olga Göransson 2015 In : Journal of Cell Science. 128, 3, p. 472-486

    Research output: Contribution to journalArticle

  9. 2014
  10. 2013
  11. A link between GIP and osteopontin in adipose tissue and insulin resistance.

    Ahlqvist, E. , Osmark, P. , Kuulasmaa, T. , Pilgaard, K. , Omar, B. , Brøns, C. , Kotova, O. , Zetterqvist, A. , Stancáková, A. , Jonsson, A. , Hansson, O. , Kuusisto, J. , Kieffer, T. J. , Tuomi, T. , Isomaa, B. , Madsbad, S. , Gomez, M. F. , Poulsen, P. , Laakso, M. , Degerman, E. & 5 others Pihlajamäki, J., Nils Wierup, Allan Vaag, Leif Groop & Valeriya Lyssenko 2013 In : Diabetes. 62, 6, p. 2088-2094

    Research output: Contribution to journalArticle

  12. A Role for Phosphodiesterase 3B in Acquisition of Brown Fat Characteristics by White Adipose Tissue in Male Mice.

    Guirguis, E., Hockman, S., Chung, Y. W., Ahmad, F., Gavrilova, O., Raghavachari, N., Yang, Y., Niu, G., Chen, X., Yu, Z. X., Liu, S., Eva Degerman & Manganiello, V. 2013 In : Endocrinology. 154, 9, p. 3152-3167

    Research output: Contribution to journalArticle

  13. Expression of insulin signalling components in the sensory epithelium of the human saccule.

    Eva Degerman, Uwe Rauch, Lindberg, S., Caye-Thomasen, P., Anna Hultgårdh & Måns Magnusson 2013 In : Cell and Tissue Research. 352, 3, p. 469-478

    Research output: Contribution to journalArticle

  14. 2012
  15. Cyclic Nucleotide Phosphodiesterase 3 Signaling Complexes

    Ahmad, F., Eva Degerman & Manganiello, V. C. 2012 In : Hormone and Metabolic Research. 44, 10, p. 776-785

    Research output: Contribution to journalReview article

  16. Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.

    Andersson, S. A., Olsson, A. H., Esguerra, J. L. S., Heimann, E., Ladenvall, C., Anna Edlund, S Albert Salehi, Taneera, J., Eva Degerman, Leif Groop, Charlotte Ling & Lena Eliasson 2012 In : Molecular and Cellular Endocrinology. 364, 1-2, p. 36-45

    Research output: Contribution to journalArticle

  17. Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion

    Tian, G., Sagetorp, J., Xu, Y., Shuai, H., Eva Degerman & Tengholm, A. 2012 In : Journal of Cell Science. 125, 21, p. 5084-5095

    Research output: Contribution to journalArticle

  18. 2011
  19. From PDE3B to the regulation of energy homeostasis.

    Eva Degerman, Ahmad, F., Chung, Y. W., Guirguis, E., Omar, B., Stenson, L. & Manganiello, V. 2011 In : Current Opinion in Pharmacology. 11, p. 676-682

    Research output: Contribution to journalArticle

  20. Insulin Reduces Neuronal Excitability by Turning on GABA(A) Channels that Generate Tonic Current

    Jin, Z., Jin, Y., Kumar-Mendu, S., Eva Degerman, Leif Groop & Birnir, B. 2011 In : PLoS ONE. 6, 1

    Research output: Contribution to journalArticle

  21. Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties.

    Nilsson, J., Shteinman, A. A., Eva Degerman, Enyedy, E. A., Kiss, T., Behrens, U., Rehder, D. & Nordlander, E. 2011 In : Journal of Inorganic Biochemistry. 105, p. 1795-1800

    Research output: Contribution to journalArticle

  22. 2010
  23. Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.

    Heimann, E., Jones, H., Svante Resjö, Manganiello, V. C., Stenson, L. & Eva Degerman 2010 In : PLoS ONE. 5, 12, e14191

    Research output: Contribution to journalArticle

  24. 2009
  25. Bis- and tris(pyridyl)amine-oxidovanadium complexes: characteristics and insulin-mimetic potential.

    Nilsson, J., Eva Degerman, Haukka, M., Lisensky, G. C., Garribba, E., Yoshikawa, Y., Sakurai, H., Enyedy, E. A., Kiss, T., Esbak, H., Rehder, D. & Ebbe Nordlander 2009 In : Dalton Transactions. 38, p. 7902-7911

    Research output: Contribution to journalArticle

  26. Cell-cell communication between adipocytes and pancreatic beta-cells in acoustically levitated droplets

    Santesson, S., Eva Degerman, Rorsman, P., Johansson, T., Lemos, S. & Staffan Nilsson 2009 In : Integrative Biology. 1, 10, p. 595-601

    Research output: Contribution to journalArticle

  27. Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta(3)-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes

    Ahmad, F., Lindh, R., Tang, Y., Ruishalme, I., Ost, A., Sahachartsiri, B., Stralfors, P., Eva Degerman & Manganiello, V. C. 2009 In : Biochemical Journal. 424, p. 399-410

    Research output: Contribution to journalArticle

  28. Regulation of AMP-activated protein kinase by cAMP in adipocytes: Roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis.

    Omar, B., Zmuda-Trzebiatowska, E., Manganiello, V., Olga Göransson & Eva Degerman 2009 In : Cellular Signalling. 21, p. 760-766

    Research output: Contribution to journalArticle

  29. 2008
  30. Macroporous gel particles as robust macroporous matrices for cell immobilization

    Plieva, F., Oknianska, A., Eva Degerman & Bo Mattiasson 2008 In : Biotechnology Journal. 3, 3, p. 410-417

    Research output: Contribution to journalArticle

  31. 2007
  32. beta-cell PDE3B regulates Ca(2+)-stimulated exocytosis of insulin.

    Jones, H., Nils Wierup, Vikman, J., Manganiello, V. C., Eva Degerman, Lena Eliasson & Stenson, L. 2007 In : Cellular Signalling. 19, Feb 12, p. 1505-1513

    Research output: Contribution to journalArticle

  33. Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB

    Ahmad, F., Lindh, R., Tang, Y., Weston, M., Eva Degerman & Manganiello, V. C. 2007 In : Biochemical Journal. 404, p. 257-268

    Research output: Contribution to journalArticle

  34. Long-term regulation of cyclic nucleotide phosphodiesterase type 3B and 4 in 3T3-L1 adipocytes.

    Oknianska, A., Zmuda-Trzebiatowska, E., Manganiello, V. & Eva Degerman 2007 In : Biochemical and Biophysical Research Communications. 353, 4, p. 1080-1085

    Research output: Contribution to journalArticle

  35. Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B.

    Lindh, R., Ahmad, F., Svante Resjö, Peter James, Yang, J. S., Fales, H. M., Manganiello, V. & Eva Degerman 2007 In : Biochimica et Biophysica Acta: Molecular Cell Research. 1773, 4, p. 584-592

    Research output: Contribution to journalArticle

  36. Novel mechanisms of the regulation of Protein kinase B in adipocytes; implications for Protein kinase A, Epac, Phosphodiesterases 3 and 4.

    Zmuda-Trzebiatowska, E., Manganiello, V. & Eva Degerman 2007 In : Cellular Signalling. 19, 1, p. 81-86

    Research output: Contribution to journalArticle

  37. Perilipin and adipophilin expression in lipid loaded macrophages

    Persson, J., Eva Degerman, Jan Nilsson & Lindholm, M. 2007 In : Biochemical and Biophysical Research Communications. 363, 4, p. 1020-1026

    Research output: Contribution to journalArticle

  38. Re-discovering PDE3 inhibitors - New opportunities for a long neglected target

    Thompson, P. E., Manganiello, V. & Eva Degerman 2007 In : Current Topics in Medicinal Chemistry. 7, 4, p. 421-436

    Research output: Contribution to journalReview article

  39. Regulation of cyclic nucleotide phosphodiesterase 3 (PDE3)

    Manganiello, V. C., Ahmad, F., Choi, Y. H., Tang, Y., Lindh, R., ZmudaTrzebiatowska, E., Walz, H., Karin Berger, Sheng, W., Liu, H., Hockman, S., Park, S., Stenson, L. & Eva Degerman 2007 Mie University Press.

    Research output: Book/ReportBook

  40. 2006
  41. Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice

    Choi, Y. H., Park, S., Hockman, S., Zmuda-Trzebiatowska, E., Svennelid, F., Haluzik, M., Gavrilova, O., Ahmad, F., Pepin, L., Napolitano, M., Taira, M., Frank Sundler, Stenson, L., Eva Degerman & Manganiello, V. C. 2006 In : Journal of Clinical Investigation. 116, 12, p. 3240-3251

    Research output: Contribution to journalArticle

  42. Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.

    Jones, H., Härndahl, L., Nils Wierup, Zmuda-Trzebiatowska, E., Svennelid, F., Manganiello, V. C., Ploug, T., Frank Sundler, Eva Degerman, Bo Ahrén & Holst, L. S. 2006 In : Journal of Endocrinology. 189, 3, p. 629-641

    Research output: Contribution to journalArticle

  43. Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes

    Liu, H., Tang, J. R., Choi, Y. H., Napolitano, M., Hockman, S., Taira, M., Eva Degerman & Manganiello, V. C. 2006 In : Journal of Biological Chemistry. 281, 30, p. 21096-21113

    Research output: Contribution to journalArticle

  44. Novel supermacroporous dextran gels

    Plieva, F., Oknianska, A., Eva Degerman, Galaev, I. & Bo Mattiasson 2006 In : Journal of Biomaterials Science. Polymer Edition. 17, 10, p. 1075-1092

    Research output: Contribution to journalArticle

  45. Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes.

    Nilsson, R., Ahmad, F., Karl Swärd, Ulrika Axling, Weston, M., Manganiello, V. & Eva Degerman 2006 In : Cellular Signalling. 18, 2006 Feb 24, p. 1713-1721

    Research output: Contribution to journalArticle

  46. Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.

    Zmuda-Trzebiatowska, E., Oknianska, A., Manganiello, V. & Eva Degerman 2006 In : Cellular Signalling. 18, 3, p. 382-390

    Research output: Contribution to journalArticle

  47. 2005
  48. Identification of promoter elements in 5'-flanking region of murine cyclic nucleotide phosphodiesterase 3B gene

    Liu, H., Tang, J. R., Eva Degerman & Manganiello, V. C. 2005 Phosphodiesterase Methods and Protocols (Methods in molecular biology). Humana Press, Vol. 307, p. 109-124

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

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