Håkan Axelson

Professor

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Kidney cancer, diagnosis, Cell signalling

Research

Solid tumors are consistently less well-oxygenated than the normal tissues from which they arise. Associations between tumor hypoxia and aggressively malignant phenotypes are observed across a range of cancers, focusing attention on molecular dissection of these pathways and how they contribute to tumorigenesis.  Clear cell renal cell carcinoma (ccRCC) is characterized by a loss of the tumor suppressor gene VHL, and hence this tumor type is characterized by constitutive activation of the hypoxic response. As such, it represents a model system for tumor hypoxia in general. Our research is aimed at identifying and characterizing the different cell types from which kidney cancer is thought to develop, and to characterize how they respond to hypoxia and loss of VHL. We have also defined as a novel ccRCC specific biomarker, SLC6A3, and explore the diagnostic and therapeutic potential of this protein. We have previously shown that hyperactivated Notch signaling may complement loss of VHL in the formation of ccRCC. Based on these findings we are establishing a model system for ccRCC based on conditional deletion of VHL in conjunction with constitutive activation of the Notch signaling pathway.

Highlighted research outputs

Kristoffer von Stedingk, De Preter, K., Vandesompele, J., Noguera, R., Ingrid Øra, Koster, J., Versteeg, R., Sven Påhlman, David Lindgren & Håkan Axelson 2015 In : International Journal of Cancer. 137, 4, p. 868-877

Research output: Contribution to journalArticle

Rankin, E. B., Fuh, K. C., Castellini, L., Viswanathan, K., Finger, E. C., Diep, A. N., LaGory, E. L., Kariolis, M. S., Chan, A., David Lindgren, Håkan Axelson, Miao, Y. R., Krieg, A. J. & Giaccia, A. J. 2014 In : Proceedings of the National Academy of Sciences. 111, 37, p. 13373-13378

Research output: Contribution to journalArticle

Jennifer Hansson, Hultenby, K., Cramnert, C., Pontén, F., Jansson, H., David Lindgren, Håkan Axelson & Martin Johansson 2014 In : Human Pathology. 45, 2, p. 382-393

Research output: Contribution to journalArticle

Jonas Sjölund, Martin Johansson, Manna, S., Norin, C., Alexander Pietras, Beckman, S., Nilsson, E., Ljungberg, B. & Håkan Axelson 2008 In : Journal of Clinical Investigation. 118, 1, p. 217-228

Research output: Contribution to journalArticle

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