Håkan Olssonaffiliated with the university, senior consultant, head physician, senior consultant´, PhD

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences
  • Cancer and Oncology

Keywords

  • Cancer epidemiology, Cancer genetics, Tumour biology

Research

New predisposing genes in common malignancies and their interaction with non genetic risk factor.

Our research overall aim is to identify new modes of inheritance and predisposing genes in common malignant disease such as breast-, ovarian cancer and melanoma and also to study gene environment interactions and modifying genes affecting the penetrance and tumour panorama for strong genes as BRCA1/2 and CDKN2A.  We have a diversified approach to identify new modes of inheritance.

Firstly cancer  genetic information is collected by clinical materials and on going epidemiologic studies. Interesting families are expanded by help of tax authorities and DNA is collected from probands and/or other family members for targeted mutational analysis, exome or whole genome sequencing. Secondly we take part in large international GWAS studies to identify genes of low penetrance or modifying genes. Thirdly by using tumour biology information genetic subgroups of tumour types can more readily be identified.

Highlighted research outputs

Ovarian Cancer:, C. G. O. E. S. O. , Calle, E. E. , Rodriguez, C. , Talamini, R. , Hankinson, S. E. , Tworoger, S. S. , Chetrit, A. , Hirsh-Yechezkel, G. , Lubin, F. , Sadetzki, S. , Appleby, P. , Banks, E. , Beral, V. , Berrington de Gonzalez, A. , Bull, D. , Crossley, B. , Goodill, A. , Green, I. , Green, J. , Hermon, C. & 95 others Key, T., Reeves, G., Collins, R., Doll, R., Peto, R., Gonzalez, C. A., Lee, N., Marchbanks, P., Ory, H. W., Peterson, H. B., Wingo, P. A., Martin, N., Pardthaisong, T., Silpisornkosol, S., Theetranont, C., Boosiri, B., Chutivongse, S., Jimakorn, P., Virutamasen, P., Wongsrichanalai, C., Titus-Ernstoff, L., Mosgaard, B. J., Vessey, M., Yeates, D., Chang-Claude, J., Rossing, M. A., Thomas, D., Weiss, N., Franceschi, S., La Vecchia, C., Negri, E., Adami, H. O., Magnusson, C., Riman, T., Weiderpass, E., Wolk, A., Freedman, D. M., Hartge, P., Lacey, J. M., Hoover, R., Schouten, L. J., van den Brandt, P. A., Chantarakul, N., Koetsawang, S., Rachawat, D., Graff-Iversen, S., Selmer, R., Bain, C. J., Green, A. C., Purdie, D. M., Siskind, V., Webb, P. M., McCann, S. E., Hannaford, P., Kay, C., Binns, C. W., Lee, A. H., Zhang, M., Nasca, P., Coogan, P. F., Rosenberg, L., Kelsey, J., Paffenbarger, R., Whittemore, A., Katsouyanni, K., Trichopoulou, A., Trichopoulos, D., Tzonou, A., Dabancens, A., Martinez, L., Molina, R., Salas, O., Goodman, M. T., Laurie, G., Carney, M. E., L R Wilkens, L. R., Bladström, A., Håkan Olsson, Ness, R. B., Grisso, J. A., Morgan, M., Wheeler, J. E., Peeters, P., Casagrande, J., Pike, M. C., Ross, R. K., Wu, A. H., Kumle, M., Lund, E., McGowan, L., Shu, X. O., Zheng, W., Farley, T. M. M., Holck, S. & Meirik, O. 2008 In : The Lancet. 371, 9609, p. 303-314

Research output: Contribution to journalArticle

Bertolotto, C. , Lesueur, F. , Giuliano, S. , Strub, T. , de Lichy, M. , Bille, K. , Dessen, P. , d'Hayer, B. , Mohamdi, H. , Remenieras, A. , Maubec, E. , de la Fouchardiere, A. , Molinie, V. , Vabres, P. , Dalle, S. , Poulalhon, N. , Martin-Denavit, T. , Thomas, L. , Andry-Benzaquen, P. , Dupin, N. & 36 others Boitier, F., Rossi, A., Perrot, J-L., Labeille, B., Robert, C., Escudier, B., Caron, O., Brugieres, L., Saule, S., Gardie, B., Gad, S., Richard, S., Couturier, J., Teh, B. T., Ghiorzo, P., Pastorino, L., Puig, S., Badenas, C., Håkan Olsson, Christian Ingvar, Rouleau, E., Lidereau, R., Bahadoran, P., Vielh, P., Corda, E., Blanche, H., Zelenika, D., Galan, P., Chaudru, V., Lenoir, G. M., Lathrop, M., Davidson, I., Avril, M-F., Demenais, F., Ballotti, R. & Bressac-de Paillerets, B. 2011 In : Nature. 480, 7375, p. 94-U259

Research output: Contribution to journalArticle

Barrett, J. H. , Iles, M. M. , Harland, M. , Taylor, J. C. , Aitken, J. F. , Andresen, P. A. , Akslen, L. A. , Armstrong, B. K. , Avril, M-F. , Azizi, E. , Bakker, B. , Bergman, W. , Bianchi-Scarra, G. , Bressac-de Paillerets, B. , Calista, D. , Cannon-Albright, L. A. , Corda, E. , Cust, A. E. , Debniak, T. , Duffy, D. & 55 others Dunning, A. M., Easton, D. F., Friedman, E., Galan, P., Ghiorzo, P., Giles, G. G., Hansson, J., Hocevar, M., Hoeiom, V., Hopper, J. L., Christian Ingvar, Janssen, B., Jenkins, M. A., Göran B Jönsson, Kefford, R. F., Landi, G., Landi, M. T., Lang, J., Lubinski, J., Mackie, R., Malvehy, J., Martin, N. G., Molven, A., Montgomery, G. W., van Nieuwpoort, F. A., Novakovic, S., Håkan Olsson, Pastorino, L., Puig, S., Puig-Butille, J. A., Randerson-Moor, J., Snowden, H., Tuominen, R., VanBelle, P., van der Stoep, N., Whiteman, D. C., Zelenika, D., Han, J., Fang, S., Lee, J. E., Wei, Q., Lathrop, G. M., Gillanders, E. M., Brown, K. M., Goldstein, A. M., Kanetsky, P. A., Mann, G. J., MacGregor, S., Elder, D. E., Amos, C. I., Hayward, N. K., Gruis, N. A., Demenais, F., Bishop, J. A. N. & Bishop, D. T. 2011 In : Nature Genetics. 43, 11, p. 1108-U98

Research output: Contribution to journalArticle

MacGregor, S. , Montgomery, G. W. , Liu, J. Z. , Zhao, Z. Z. , Henders, A. K. , Stark, M. , Schmid, H. , Holland, E. A. , Duffy, D. L. , Zhang, M. , Painter, J. N. , Nyholt, D. R. , Maskiell, J. A. , Jetann, J. , Ferguson, M. , Cust, A. E. , Jenkins, M. A. , Whiteman, D. C. , Olsson, H. , Puig, S. & 32 others Bianchi-Scarra, G., Hansson, J., Demenais, F., Landi, M. T., Debniak, T., Mackie, R., Azizi, E., Bressac-de Paillerets, B., Goldstein, A. M., Kanetsky, P. A., Gruis, N. A., Elder, D. E., Newton-Bishop, J. A., Bishop, D. T., Iles, M. M., Helsing, P., Amos, C. I., Wei, Q., Wang, L-E., Lee, J. E., Qureshi, A. A., Kefford, R. F., Giles, G. G., Armstrong, B. K., Aitken, J. F., Han, J., Hopper, J. L., Trent, J. M., Brown, K. M., Martin, N. G., Mann, G. J. & Hayward, N. K. 2011 In : Nature Genetics. 43, 11, p. 1114-U104

Research output: Contribution to journalArticle

Law, M. H. , Bishop, D. T. , Lee, J. E. , Brossard, M. , Martin, N. G. , Moses, E. K. , Song, F. , Barrett, J. H. , Kumar, R. , Easton, D. F. , Pharoah, P. D. P. , Swerdlow, A. J. , Kypreou, K. P. , Taylor, J. C. , Harland, M. , Randerson-Moor, J. , Akslen, L. A. , Andresen, P. A. , Avril, M-F. , Azizi, E. & 55 others Scarrà, G. B., Brown, K. M., Dȩbniak, T., Duffy, D. L., Elder, D. E., Fang, S., Friedman, E., Galan, P., Ghiorzo, P., Gillanders, E. M., Goldstein, A. M., Gruis, N. A., Hansson, J., Helsing, P., Hočevar, M., Höiom, V., Christian Ingvar, Kanetsky, P. A., Chen, W. V., Landi, M. T., Lang, J., Lathrop, G. M., Lubiński, J., Mackie, R. M., Mann, G. J., Molven, A., Montgomery, G. W., Novaković, S., Håkan Olsson, Puig, S., Puig-Butille, J. A., Qureshi, A. A., Radford-Smith, G. L., van der Stoep, N., van Doorn, R., Whiteman, D. C., Craig, J. E., Schadendorf, D., Simms, L. A., Burdon, K. P., Nyholt, D. R., Pooley, K. A., Orr, N., Stratigos, A. J., Cust, A. E., Ward, S. V., Hayward, N. K., Han, J., Schulze, H-J., Dunning, A. M., Bishop, J. A. N., Demenais, F., Amos, C. I., MacGregor, S. & Iles, M. M. 2015 In : Nature Genetics. 47, 9, p. 987

Research output: Contribution to journalArticle

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