Heiko HerwaldProfessor, Medical Microbial Pathogenesis

Research areas and keywords

UKÄ subject classification

  • Medical and Health Sciences
  • Microbiology in the medical area
  • Immunology in the medical area


Modulation of inflammatory responses to bacterial infections

Severe infectious diseases, including sepsis, remain a serious medical challenge worldwide. Clinical symptoms of patients suffering from sepsis are a culmination of complex interactions between the infecting microorganism and host immune responses, such as the induction of overwhelming inflammatory reactions, systemic activation of the coagulation system, and impaired fibrinolysis. These alarming findings prompted many research groups, including my own, to search for novel strategies to treat severe infectious diseases. Many of these approaches are focused on so-called “host effector systems”, since evidence has accumulated that complications from an infection are caused by an over-stimulation of host defense systems that are modulated by bacteria or bacterial products. In severe infections, such as sepsis and septic shock, vascular leakage, increased cytokine levels, and coagulation/fibrinolysis dysfunction are often observed.

My research projects aim to identify and characterize molecular mechanisms that lead to these complications. To accomplish these tasks various in vitro, ex vivo, and in vivo models will be employed. The results obtained from our investigations have a chance to open new routes for development of diagnostic tools and the discovery of novel treatments in severe infectious diseases.

Recent research outputs

Halldorsdottir, H. D., Eriksson, J., Persson, B. P., H. Herwald, Lindbom, L., Weitzberg, E. & Oldner, A. 2018 Mar 22 In : Acta Anaesthesiologica Scandinavica.

Research output: Contribution to journalArticle

Anders, E., Nebel, D., Westman, J., Heiko Herwald, Bengt Olof Nilsson & Daniel Svensson 2018 Feb 28 In : Biochemical Journal. 475, 4, p. 775-786 12 p.

Research output: Contribution to journalArticle

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