Martin Johansson

Senior Lecturer, Consultant

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • kidney , regeneration , cancer

Research

The kidneys are highly complex organs that excrete toxins and metabolic end products, but also control major homeostatic parameters such as blood pressure, electrolyte balance and pH. Kidney disease may often become life threatning and renal disease is increasing at almost epidemic rates globally.

We study kidney disease, with focus on two main fields of investigation.

I. KIDNEY REGENERATION. Kidney injury occurs only if the the disease overruns the regenerative capacity of the kidney. It is still unclear how the human kidney regenerates however. We were first to describe a scattered cell population localized to the proximal tubules of the human kidney that are associated with kidney regeneration. The cells are progenitor like and display a radically different metabolic profile as compared to the neighbouring cells. We are currently researching the regulation of these cells.


II. RENAL CELL CARCINOMA. Renal cell carcinoma (RCC) occurs in many forms. The most common (80%) and malignant type is clear cell RCC (ccRCC). A notable and uncommon feature of ccRCC is, that if not surgically resected, the patient will invariably die, since neither radiation nor cytostatics have any effect on the progression. This cancer is caused by unique changes of cellular metabolism caused by the induction of a pseudo hypoxic state due to bi-allelic loss of the VHL gene. We study this aberrant metabolism with the ultimate goal to develop novel treatment principles based on metabolic intervention.

Recent research outputs

Ekstrand, M., Widell, E., Hammar, A., Akyürek, L. M., Martin Johansson, Fagerberg, B., Bergström, G., Levin, M. C., Fogelstrand, P., Borén, J. & Levin, M. 2017 Jun 1 In : PLoS ONE. 12, 6, p. 1-10 e0178877

Research output: Contribution to journalArticle

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