Olga Göransson

Senior Lecturer

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology
  • Endocrinology and Diabetes
  • Cell Biology
  • Physiology

Keywords

Research

Protein phosphorylation is a signalling mechanism that regulates most aspects of cellular life, and protein kinases, which carry out this post-translational modification, constitute the largest family of enzymes encoded by the human genome. Defects in signal transduction is a mechanism contributing to the development of both cancer and diabetes. Increased knowledge about protein kinase signalling is thus needed to prevent and treat these diseases.

An overall aim of our research is to study the regulation and function of protein phosphorylation cascades with relevance to type 2 diabetes, with a particular focus on adipose tissue, since this tissue is involved in the pathogenesis of diabetes. Presently, our main project evolves around the amp-activated protein kinase (ampk) family, which consists of ampk and another 12 related kinases, of which we are particularly interested in the salt-inducible kinases (1-3). We have shown that sik2 is down-regulated in adipose tissue from obese individuals and are currently investigating the role of sik2 in the development of diabetes. Ampk is a target for new and existing diabetes therapy, and our research will predict effects of such therapy in adipose tissue. 

Teaching

I am highly engaged in leading, organizing and executing teaching at the medical- and biomedical programmes, as well as at the research level - my main teaching subjects being cell biology and diabetology. I'm currently co-responsible for the 1st semester of the medical programme, which includes the two courses Knowledge and learning and Molecule to tissue, the latter in which I hold a PBL-tutorship.

Moreover, I have functioned as the course leader and/or examiner for the course Molecular Cell Biology, in the Biomedicine Programme for several years, and am a member of the committee for master programmes at the Medical Faculty.

In the PhD programme I'm responsible for the course Generic Knowledge and skills, which is tought and assessed through the completion of a portfolio. The prupose of the course is to give students the posssibility to attain and demonstrate degree outcomes that are not directly inked to their thesis work.

 

Outreach

I regard external engagement important and rewarding and I have participated in several outreach activities, such as "Forskningens Dag 2015 - " and the NMT-days, where I lectured on the topics "How fat cells work" and "The fat cell - friend or foe?".

https://www.youtube.com/watch?v=eTbSP2Hdv68

http://www.vetenskaphalsa.se/hon-vill-forsta-hur-fetma-kan-leda-till-insulinresistens/

 

 

Recent research outputs

Björn Hansson, Sebastian Wasserstrom, Björn Morén, Periwal, V., Petter Vikman, Cushman, S. W., Olga Göransson, Storm, P. & Karin G. Stenkula, 2018 Apr 1, In : Journal of Molecular Endocrinology. 60, 3, p. 199-211 13 p.

Research output: Contribution to journalArticle

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