Patrik Önnerfjord

Researcher, Associate professor
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  1. 2018
  2. Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ

    Tang, X., Muhammad, H., McLean, C., Miotla-Zarebska, J., Fleming, J., Didangelos, A., Patrik Önnerfjord, Leask, A., Saklatvala, J. & Vincent, T. L., 2018 Jun 20, In : Annals of the Rheumatic Diseases.

    Research output: Contribution to journalArticle

  3. 2017
  4. Cartilage oligomeric matrix protein neoepitope in the synovial fluid of horses with acute lameness: A new biomarker for the early stages of osteoarthritis

    Skiöldebrand, E., Ekman, S., Mattsson-Hultén, L., Svala, E., Björkman, K., Lindahl, A., Lundqvist, A., P. Önnerfjord, Sihlbom, C. & Rüetschi, U., 2017 Sep, In : Equine Veterinary Journal. 49, 5, p. 662-667

    Research output: Contribution to journalArticle

  5. Cartilage matrix remodelling differs by disease state and joint type

    Hsueh, M-F., Kraus, V. B. & P Önnerfjord, 2017 Aug 24, In : European cells & materials. 34, p. 70-82 13 p.

    Research output: Contribution to journalArticle

  6. Differences in biomarkers of cartilage matrix turnover and their changes over 2 years in adolescent and adult volleyball athletes

    Boeth, H., MacMahon, A., Poole, A. R., Buttgereit, F., Patrik Önnerfjord, Pilar Lorenzo, Klint, C., Pramhed, A. & Duda, G. N., 2017, In : Journal of Experimental Orthopaedics. 4, 7

    Research output: Contribution to journalArticle

  7. Quantitative proteomics analysis of cartilage response to mechanical injury and cytokine treatment

    Wang, Y., Li, Y., Khabut, A., Chubinskaya, S., Grodzinsky, A. J. & Patrik Önnerfjord, 2017, In : Matrix Biology. 63, p. 11-22

    Research output: Contribution to journalArticle

  8. The minor collagens in articular cartilage

    Luo, Y., Dovile Sinkeviciute, He, Y., Karsdal, M. A., Henrotin, Y., Mobasheri, A., Patrik Önnerfjord & Bay-Jensen, A., 2017, In : Protein and Cell. 8, 8, p. 560-572

    Research output: Contribution to journalArticle

  9. 2016
  10. The Tyrosine Sulfate Domain of Fibromodulin Binds Collagen and Enhances Fibril Formation

    Viveka Tillgren, Mörgelin, M., Patrik Önnerfjord, Kalamajski, S. & Anders Aspberg, 2016 Nov 4, In : Journal of Biological Chemistry. 291, 45, p. 23744-23755 12 p.

    Research output: Contribution to journalArticle

  11. Elucidating the Molecular Composition of Cartilage by Proteomics

    Hsueh, M. F., Khabut, A., Sven Kjellström, Patrik Önnerfjord & Kraus, V. B., 2016 Feb 5, In : Journal of Proteome Research. 15, 2, p. 374-388 15 p.

    Research output: Contribution to journalArticle

  12. Chondrocytes derived from mesenchymal stromal cells and induced pluripotent cells of patients with familial osteochondritis dissecans exhibit an endoplasmic reticulum stress response and defective matrix assembly

    Xu, M., Stattin, E. L., Shaw, G., Heinegård, D., Sullivan, G., Wilmut, I., Colman, A., Patrik Önnerfjord, Khabut, A., Anders Aspberg, Dockery, P., Hardingham, T., Murphy, M. & Barry, F., 2016, In : Stem cells translational medicine. 5, 9, p. 1171-1181 11 p.

    Research output: Contribution to journalArticle

  13. 2015
  14. OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis.

    Kraus, V. B., Blanco, F. J., Englund, M., Henrotin, Y., Stefan Lohmander, Losina, E., Patrik Önnerfjord & Persiani, S., 2015, In : Osteoarthritis and Cartilage. 23, 5, p. 686-697

    Research output: Contribution to journalReview article

  15. The α2β1 binding domain of chondroadherin inhibits breast cancer-induced bone metastases and impairs primary tumour growth: A preclinical study.

    Rucci, N., Capulli, M., Olstad, O. K., Patrik Önnerfjord, Viveka Tillgren, Gautvik, K. M., Heinegård, D. & Teti, A., 2015, In : Cancer Letters. 358, 1, p. 67-75

    Research output: Contribution to journalArticle

  16. 2014
  17. Articular cartilage

    Heinegård, D., Pilar Lorenzo, Patrik Önnerfjord & Tore Saxne, 2014, Rheumatology. Hochberg, MC., Silman, AJ., Smolen, JS., Weinblatt, ME. & Weisman, MH. (eds.). 6 ed. Philadelphia: Mosby-Elsevier, p. 33-41

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  18. Biomarkers and proteomic analysis of osteoarthritis.

    Hsueh, M-F., Patrik Önnerfjord & Kraus, V. B., 2014, In : Matrix Biology. 39, Aug 30, p. 56-66

    Research output: Contribution to journalReview article

  19. Nanomechanical phenotype of chondroadherin-null murine articular cartilage.

    Batista, M. A., Nia, H. T., Patrik Önnerfjord, Cox, K. A., Ortiz, C., Grodzinsky, A., Heinegård, D. & Han, L., 2014, In : Matrix Biology. 38, Jun 2, p. 84-90

    Research output: Contribution to journalArticle

  20. Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein)*

    Dakin, S. G., Smith, R. K. W., Heinegård, D., Patrik Önnerfjord, Khabut, A. & Dudhia, J., 2014, In : Journal of Biological Chemistry. 289, 8, p. 4919-4927

    Research output: Contribution to journalArticle

  21. Quantitative proteomics at different depths in human articular cartilage reveals unique patterns of protein distribution.

    Catharina Muller, Khabut, A., Dudhia, J., Reinholt, F. P., Anders Aspberg, Heinegård, D. & Patrik Önnerfjord, 2014, In : Matrix Biology. 40, Sep 1, p. 34-45

    Research output: Contribution to journalArticle

  22. The C-Terminal Domain of Chondroadherin: A New Regulator of Osteoclast Motility Counteracting Bone Loss

    Capulli, M., Olstad, O. K., Patrik Önnerfjord, Viveka Tillgren, Muraca, M., Gautvik, K. M., Heinegård, D., Rucci, N. & Teti, A., 2014, In : Journal of Bone and Mineral Research. 29, 8, p. 1833-1846

    Research output: Contribution to journalArticle

  23. 2013
  24. Chondroadherin Fragmentation Mediated by the Protease HTRA1 Distinguishes Human Intervertebral Disc Degeneration from Normal Aging

    Akhatib, B., Patrik Önnerfjord, Gawri, R., Ouellet, J., Jarzem, P., Heinegård, D., Mort, J., Roughley, P. & Haglund, L., 2013, In : Journal of Biological Chemistry. 288, 26, p. 19280-19287

    Research output: Contribution to journalArticle

  25. The skeletal phenotype of chondroadherin deficient mice.

    Hessle, L., Stordalen, G. A., Wenglén, C., Petzold, C., Tanner, E. K., Brorson, S-H., Baekkevold, E. S., Patrik Önnerfjord, Reinholt, F. P. & Heinegård, D., 2013, In : PLoS ONE. 8, 6, e63080

    Research output: Contribution to journalArticle

  26. 2012
  27. Quantitative Proteomic Analysis of Eight Cartilaginous Tissues Reveals Characteristic Differences as well as Similarities between Subgroups.

    Patrik Önnerfjord, Khabut, A., Reinholt, F. P., Svensson, O. & Heinegård, D., 2012, In : Journal of Biological Chemistry. 287, 23, p. 18913-18924

    Research output: Contribution to journalArticle

  28. 2010
  29. A Missense Mutation in the Aggrecan C-type Lectin Domain Disrupts Extracellular Matrix Interactions and Causes Dominant Familial Osteochondritis Dissecans

    Stattin, E-L., Wiklund, F., Lindblom, K., Patrik Önnerfjord, Jonsson, B-A., Tegner, Y., Sasaki, T., André Struglics, Stefan Lohmander, Dahl, N., Heinegård, D. & Aspberg, A., 2010, In : American Journal of Human Genetics. 86, 2, p. 126-137

    Research output: Contribution to journalArticle

  30. Characterisation Of Various Human Cartilage Subtypes Using Quantitative Proteomics Reveals Unique Protein Patterns

    Patrik Önnerfjord, Khabut, A., Reinholt, F. & Heinegård, D., 2010, In : Osteoarthritis and Cartilage. 18, p. S227-S227

    Research output: Contribution to journalPublished meeting abstract

  31. 2009
  32. Changes in proteasome structure and function caused by HAMLET in tumor cells.

    Gustafsson, L., Sonja Aits, Patrik Önnerfjord, Trulsson, M., Storm, P. & Catharina Svanborg, 2009, In : PLoS ONE. 4, 4, e5229

    Research output: Contribution to journalArticle

  33. Interactions of histidine-rich glycoprotein with immunoglobulins and proteins of the complement system.

    Manderson, G., Martin, M., Patrik Önnerfjord, Tore Saxne, Artur Schmidtchen, Mollnes, T. E., Heinegård, D. & Blom, A. M., 2009, In : Molecular Immunology. Aug 10, p. 3388-3398

    Research output: Contribution to journalArticle

  34. Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion.

    Ruben Smith, Karl Bacos, Fedele, V., Soulet, D., Jones, H., Obermüller, S., Lindqvist, A., Maria Björkqvist, Klein, P., Patrik Önnerfjord, Brundin, P., Hindrik Mulder & Jia-Yi Li, 2009, In : Human Molecular Genetics. 18, 20, p. 3942-3954

    Research output: Contribution to journalArticle

  35. 2008
  36. Altered osteoclast development and function in osteopontin deficient mice.

    Franzén, A., Hultenby, K., Reinholt, F. P., Patrik Önnerfjord & Heinegård, D., 2008, In : Journal of Orthopaedic Research. 26, 5, p. 721-728

    Research output: Contribution to journalArticle

  37. Proteomic analysis of the LPS-induced stress response in rat chondrocytes reveals induction of innate immune response components in articular cartilage

    Haglund, L., Bernier, S. M., Patrik Önnerfjord & Recklies, A. D., 2008, In : Matrix Biology. 27, 2, p. 107-118

    Research output: Contribution to journalArticle

  38. The role of histidine rich glycoprotein in the modulation of immune function

    Manderson, G., Myriam Martin, Patrik Önnerfjord, Heinegård, D. & Anna Blom, 2008, In : Molecular Immunology. 45, 16, p. P115

    Research output: Contribution to journalPublished meeting abstract

  39. UCMA, a novel secreted cartilage-specific protein with implications in osteogenesis

    Surmann-Schmitt, C., Dietz, U., Kireva, T., Adam, N., Park, J., Tagariello, A., Patrik Önnerfjord, Heinegård, D., Schlotzer-Schrehardt, U., Deutzmann, R., von der Mark, K. & Stock, M., 2008, In : Journal of Biological Chemistry. 283, 11, p. 7082-7093

    Research output: Contribution to journalArticle

  40. 2007
  41. Fragmentation of proteins in cartilage treated with IL-1. Specific cleavage of type IX collagen by MMP-13 releases the NC4 domain.

    Danfelter, M., Patrik Önnerfjord & Heinegård, D., 2007, In : Journal of Biological Chemistry. 282, 51, p. 36933-36941

    Research output: Contribution to journalArticle

  42. 2006
  43. Binding mitochondria to cryogel monoliths allows detection of proteins specifically released following permeability transition

    Teilum, M., Magnus Hansson, Dainiak, M., Månsson, R., Surve, S., Eskil Elmer, Patrik Önnerfjord & Gustav Mattiasson, 2006, In : Analytical Biochemistry. 348, 2, p. 209-221

    Research output: Contribution to journalArticle

  44. 2005
  45. The extracellular matrix and inflammation - Fibromodulin activates the classical pathway of complement by directly binding C1q

    Holmér, A., Patrik Önnerfjord, Mörgelin, M., Heinegård, D. & Anna Blom, 2005, In : Journal of Biological Chemistry. 280, 37, p. 32301-32308

    Research output: Contribution to journalArticle

  46. 2004
  47. Identification of tyrosine sulfation in extracellular leucine-rich-repeat proteins using mass spectrometry.

    Patrik Önnerfjord, Heathfield, T. & Heinegård, D., 2004, In : Journal of Biological Chemistry. 279, 1, p. 26-33

    Research output: Contribution to journalArticle

  48. Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C: use of engineered disulfide bridges, antibodies, and carboxymethylpapain to stabilize the monomeric form of cystatin C

    Wahlbom, M., Wang, X., Rodziewicz-Motowidlo, S., Janowski, R., Veronica Lindström, Patrik Önnerfjord, Westermark, G., Grzonka, Z., Jaskolski, M. & Anders Grubb, 2004, In : Journal of Biological Chemistry. 279, 23, p. 24236-24245 10 p.

    Research output: Contribution to journalArticle

  49. 2003
  50. Age-related changes in the proteoglycans of human skin - Specific cleavage of decorin to yield a major catabolic fragment in adult skin

    Carrino, D. A., Patrik Önnerfjord, Sandy, J. D., Cs-Szabo, G., Scott, P. G., Heinegård, D., Sorrell, J. M. & Caplan, A. I., 2003, In : Journal of Biological Chemistry. 278, 19, p. 17566-17572

    Research output: Contribution to journalArticle

  51. 2002
  52. Calbindin D28k exhibits properties characteristic of a Ca2+ sensor.

    Berggård, T., Miron, S., Patrik Önnerfjord, Thulin, E., Akerfeldt, K. S., Enghild, J. J., Mikael Akke & Sara Linse, 2002, In : Journal of Biological Chemistry. 277, 19, p. 16662-16672

    Research output: Contribution to journalArticle

  53. 2001
  54. Enzyme flow immunoassay using a Protein G column for the screening of triazine herbicides in surface and waste water

    Bjarnason, B., Chimuka, L., Patrik Önnerfjord, Eremin, S., Jan Åke Jönsson, Johansson, G. & Emnéus, J., 2001 Jan 12, In : Analytica Chimica Acta. 426, 2, p. 197-207 11 p.

    Research output: Contribution to journalArticle

  55. 2000
  56. Development of fluorescence based flow immunoassays utilising restricted access columns

    P. Önnerfjord & G. Marko-Varga, 2000 Feb, In : Chromatographia. 51, 3-4, p. 199-204 6 p.

    Research output: Contribution to journalArticle

  57. Selective extraction of small proteins from biological samples using a novel restricted access column with cation exchange properties

    Grimm, C. H., Boos, K. S., Apel, C., Unger, K. K., P. Önnerfjord, Heintz, L., Edholm, L. E. & G. Marko-Varga, 2000, In : Chromatographia. 52, 11-12, p. 703-709 7 p.

    Research output: Contribution to journalArticle

  58. 1999
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