Pontus Nordenfelt

Associate Senior Lecturer

Research areas and keywords

UKÄ subject classification

  • Infectious Medicine
  • Cell and Molecular Biology
  • Microbiology in the medical area
  • Immunology in the medical area
  • Computer Vision and Robotics (Autonomous Systems)
  • Cell Biology
  • Biophysics
  • Bioinformatics and Systems Biology



Bacterial infections represent a major global health issue and more detailed knowledge about host-bacteria interactions are needed to counteract the rising bacterial resistance to antibiotics. The Nordenfelt Lab uses unique biosensor technology in conjunction with advanced live imaging and image analysis techniques to study initial host-pathogen interactions. The molecular surface composition of bacteria and human cells are analyzed and related to each other at a single-bacterium level, allowing for a direct link between receptor activity and the number of molecules at each interaction site. With this information it is possible start unraveling the molecular basis for the first steps of bacterial pathogenesis. The overall goal of the research is through better understanding at the molecular level open up new targets for antibacterial treatments and diagnostics.

Recent research outputs

Pontus Nordenfelt, Moore, T. I., Mehta, S. B., Kalappurakkal, J. M., Swaminathan, V., Koga, N., Lambert, T. J., Baker, D., Waters, J. C., Oldenbourg, R., Tani, T., Mayor, S., Waterman, C. M. & Springer, T. A. 2017 Dec 11 In : Nature Communications. 8, 1, 2047

Research output: Contribution to journalArticle

Swaminathan, V., Kalappurakkal, J. M., Mehta, S. B., Pontus Nordenfelt, Moore, T. I., Koga, N., Baker, D. A., Oldenbourg, R., Tani, T., Mayor, S., Springer, T. A. & Waterman, C. M. 2017 Oct 3 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 40, p. 10648-10653 6 p.

Research output: Contribution to journalArticle

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