Sofie MohlinAssociate Researcher, Engineer, MSc, PhDFormer name: Sofie Johnsson

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Pediatrics
  • Cell and Molecular Biology
  • Developmental Biology
  • Cell Biology

Keywords

Research

My research aims to understand how, when, where and why childhood tumor form neuroblastoma (NB) and adult tumor forms paraganglioma and phenochromocytoma (PPGLs) develop during normal embryogenesis. NB and PPGLs originate from cells of the sympathetic nervous system (SNS) and locate along the sympathetic and parasympathetic ganglia, most commonly within the abdominal region. The SNS in turn derives from the neural crest, an ephemeral structure that arises during nervous system formation during embryogenesis of all vertebrates.

 

I use chick embryos as my main model system, an excellent equivalent to human embryogenesis at corresponding stages of neural crest development. My projects are divided into creating novel embryonic tumor models and investigating the role of disease-associated genes and proteins during normal development to understand their potential role in tumor initation and progression.

 

Childhood tumors are difficult to detect and the majority of patients with high-risk tumors die from their disease or experience severe late effects from heavy treatment. Understanding the origin and transforming events of these tumors can lead to earlier detection of tumors and treatment at earlier stages of tumor progression, increasing the chances of successful treatment and less side effects.

Recent research outputs

Da Silva, S., Keita, Å. V., Sofie Mohlin, Sven Påhlman, Theodorou, V., Påhlman, I., Mattson, J. P. & Söderholm, J. D. 2018 Mar 19 In : Inflammatory Bowel Diseases. 24, 4, p. 792-805 14 p.

Research output: Contribution to journalArticle

View All (20)