Abnormal Metabolism of γ-Trace Alkaline Microprotein: The Basic Defect in Hereditary Cerebral Hemorrhage with Amyloidosis

Research output: Contribution to journalArticle

Abstract

ALTHOUGH the total incidence of cerebral hemorrhage is high, comparatively few reports concerning the familial occurrence of this disease have been published.1,2 In 1935 Arnason described 10 families with a high incidence of cerebral hemorrhage and concluded that a hereditary form of the disease was present in these families.3 Further clinicopathological investigations of the disease revealed an autosomal dominant inheritance and a connection between the disease and a special form of amyloidosis confined to the cerebral vasculature.4 This type of cerebral hemorrhage is therefore generally referred to as hereditary cerebral hemorrhage with amyloidosis. Recently, the fibrillar components of the amyloid.

Details

Authors
Organisations
External organisations
  • University of Iceland
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Clinical Laboratory Medicine
Original languageEnglish
Pages (from-to)1547-1549
Number of pages3
JournalNew England Journal of Medicine
Volume311
Issue number24
StatePublished - 1984 Dec 13
Publication categoryResearch
Peer-reviewedYes