Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa

Research output: Contribution to journalArticle

Abstract

During pregnancy, specific variants of Plasmodium falciparum-infected erythrocytes (IEs) can accumulate in the placenta through adhesion to chondroitin sulfate A (CSA) mediated by expression of PfEMP1 encoded by var2csa-type genes. Antibodies against these variants are associated with protection from maternal malaria. We evaluated antibodies among Kenyan, Papua New Guinean, and Malawian men and Kenyan children against two different CSA-binding P. falciparum isolates expressing var2csa variants. Specific IgG was present at significant levels among some men and children from each population, suggesting exposure to these variants is not exclusive to pregnancy. However, the level and prevalence of antibodies was substantially lower overall than exposed multigravidas. IgG-binding was specific and did not represent antibodies to subpopulations of non-CSA-binding IEs, and some sera inhibited IE adhesion to CSA. These findings have significant implications for understanding malaria pathogenesis and immunity and may be significant for understanding the acquisition of immunity to maternal malaria. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.

Details

Authors
  • J. G. Beeson
  • F. Ndungu
  • Kristina Persson
  • J. M. Chesson
  • G. L. Kelly
  • S. Uyoga
  • S. L. Hallamore
  • T. N. Williams
  • J. C. Reeder
  • G. V. Brown
  • K. Marsh
External organisations
  • Walter and Eliza Hall Institute of Medical Research
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology

Keywords

  • chondroitin-sulfate-a, variant surface-antigens, cytoadherence, characteristics, parasite adhesion, pregnant-women, var genes, distinct, adhesive, endothelial-cells, hyaluronic-acid, malaria
Original languageEnglish
Pages (from-to)22-28
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume77
Issue number1
StatePublished - 2007
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes

Bibliographic note

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