Associations of central and brachial blood pressure with cognitive function: a population-based study.

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T1 - Associations of central and brachial blood pressure with cognitive function: a population-based study.

AU - Nilsson,Erik

AU - Elmståhl,Sölve

AU - Minthon,Lennart

AU - Nilsson,Peter

AU - Pihlsgård,Mats

AU - Nägga,Katarina

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Internal Medicine Research Unit (013242520), Geriatric Medicine (013220004), Clinical Memory Research Unit (013242610), Division of Geriatric Medicine (013040040)

PY - 2015

Y1 - 2015

N2 - Previous observational studies on the association between brachial blood pressure (BP) and cognition have reported conflicting results. Central BP has been hypothesized to be more strongly related to cognition than brachial BP. The aim of this study was to assess the association between brachial as well as central BP and cognitive function, both cross-sectionally and with brachial BP measured 17 years before cognitive testing. The study population comprised 2548 individuals aged 61-85 years at follow-up (61.4% women). The cognitive tests administered were A Quick Test of cognitive speed and the Mini Mental State Examination. In fully adjusted linear regressions, small but significant cross-sectional associations were found between higher BP (systolic, diastolic and pulse pressure) and worse results on both of the cognitive tests (P-values <0.05). No significant prospective associations were found. Central BP did not show a stronger association than brachial BP did. After stratification, significant results were mainly found in the group taking BP-lowering drugs at follow-up. In summary, these findings add to existing evidence on the relationship between BP and cognition, but they do not support a superior role of central compared with brachial BP in the elderly.Journal of Human Hypertension advance online publication, 16 April 2015; doi:10.1038/jhh.2015.33.

AB - Previous observational studies on the association between brachial blood pressure (BP) and cognition have reported conflicting results. Central BP has been hypothesized to be more strongly related to cognition than brachial BP. The aim of this study was to assess the association between brachial as well as central BP and cognitive function, both cross-sectionally and with brachial BP measured 17 years before cognitive testing. The study population comprised 2548 individuals aged 61-85 years at follow-up (61.4% women). The cognitive tests administered were A Quick Test of cognitive speed and the Mini Mental State Examination. In fully adjusted linear regressions, small but significant cross-sectional associations were found between higher BP (systolic, diastolic and pulse pressure) and worse results on both of the cognitive tests (P-values <0.05). No significant prospective associations were found. Central BP did not show a stronger association than brachial BP did. After stratification, significant results were mainly found in the group taking BP-lowering drugs at follow-up. In summary, these findings add to existing evidence on the relationship between BP and cognition, but they do not support a superior role of central compared with brachial BP in the elderly.Journal of Human Hypertension advance online publication, 16 April 2015; doi:10.1038/jhh.2015.33.

U2 - 10.1038/jhh.2015.33

DO - 10.1038/jhh.2015.33

M3 - Article

JO - Journal of Human Hypertension

T2 - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 1476-5527

ER -